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Sodium picosulfate cas no:10040-45-6

Synonyms: Phenol,4,4'-(2-pyridinylmethylene)bis-, bis(hydrogen sulfate) (ester), disodium salt(9CI);Phenol, 4,4'-(2-pyridylmethylene)di-, bis(hydrogen sulfate) (ester)disodium salt (8CI);4,4'-(2-Pyridylmethylene)diphenol bis(hydrogen sulfate)disodium salt;DA 1773;Disodium bis[4-[(hydroxysulfonyl)oxy]phenyl](2-pyridyl)methane;Evacuol;Guttalax;Guttalax-Fher;LA 391;Laxoberal;Laxoberon;Neopax;Pico-Salax;Picolax;Picosulfate sodium;Picosulfol;Rapilax;Sodiumpicosulfate;

Identification
NameSodium picosulfate
CAS10040-45-6
SynonymsPhenol,4,4'-(2-pyridinylmethylene)bis-, bis(hydrogen sulfate) (ester), disodium salt(9CI);Phenol, 4,4'-(2-pyridylmethylene)di-, bis(hydrogen sulfate) (ester)disodium salt (8CI);4,4'-(2-Pyridylmethylene)diphenol bis(hydrogen sulfate)disodium salt;DA 1773;Disodium bis[4-[(hydroxysulfonyl)oxy]phenyl](2-pyridyl)methane;Evacuol;Guttalax;Guttalax-Fher;LA 391;Laxoberal;Laxoberon;Neopax;Pico-Salax;Picolax;Picosulfate sodium;Picosulfol;Rapilax;Sodiumpicosulfate;
EINECS(EC#)233-120-9
Molecular FormulaC18H13NNa2O8S2
Molecular Weight499.42
Chemical Properties
Appearancegray powder complex
Safety Data

Safety Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. A cathartic. When heated to decomposition it emits toxic fumes of SOx, NOx, and Na2O.

Toxicity
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 2900mg/kg (2900mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 341, 1977.
mouse LD50 intravenous 1600mg/kg (1600mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 341, 1977.
mouse LD50 oral 14500mg/kg (14500mg/kg) BEHAVIORAL: ATAXIA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 341, 1977.
mouse LD50 subcutaneous 6420mg/kg (6420mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Nara Igaku Zasshi. Journal of the Nara Medical Association. Vol. 28, Pg. 258, 1977.
rat LD50 intraperitoneal 3gm/kg (3000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 341, 1977.
rat LD50 intravenous 1450mg/kg (1450mg/kg) BEHAVIORAL: ATAXIA Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 341, 1977.
rat LD50 oral 11300mg/kg (11300mg/kg)   Drugs in Japan Vol. -, Pg. 993, 1995.
rat LD50 subcutaneous 6980mg/kg (6980mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: COMA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Nara Igaku Zasshi. Journal of the Nara Medical Association. Vol. 28, Pg. 258, 1977.

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