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Orthoboric acid cas no:10043-35-3

Synonyms: Boric Acid, MB Grade (1.12015); Boron; Boricacidhighpurity; Boricacidwhitextl; Boric acid - specially pure; Boric Acid BP

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Identification
NameOrthoboric acid
CAS10043-35-3
SynonymsBoric Acid, MB Grade (1.12015); Boron; Boricacidhighpurity; Boricacidwhitextl; Boric acid - specially pure; Boric Acid BP
EINECS(EC#)233-139-2
Molecular FormulaH3BO3
Molecular Weight61.83
Chemical Properties
Appearancecolourless or white odourless crystalline solid
refractive index1.462
storage tempStore at RT.
Sensitive Hygroscopic
Safety Data

Hazard T:Toxic
Risk R60
Safety

Hazard Codes:?IrritantXi,Xn ToxicT
Risk Statements: 36/37/38-60-63-62?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R60:May impair fertility.?
R63:Possible risk of harm to the unborn child.?
R62:Risk of impaired fertility.
Safety Statements: 26-36-53-45-37/39-36/37/39-22?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.?
S53:Avoid exposure - obtain special instructions before use.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S37/39:Wear suitable gloves and eye/face protection.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S22:Do not breathe dust.
WGK Germany: 2
RTECS: ED4550000
F: 3
HS Code: 28100090


HS Code 28100090

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child LDLo skin 1500mg/kg (1500mg/kg) SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"		 Quarterly Journal of Pharmacy & Pharmacology. Vol. 6, Pg. 714, 1933.
child LDLo skin 4gm/kg/4D (4000mg/kg) ? Muenchener Medicinische Wochenschrift. Vol. 52, Pg. 763, 1905.
child TDLo oral 500mg/kg (500mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Journal of Toxicology, Clinical Toxicology. Vol. 24, Pg. 269, 1986.
dog LDLo oral 1780mg/kg (1780mg/kg) BRAIN AND COVERINGS: MENINGEAL CHANGES

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: NAUSEA OR VOMITING		 JAMA, Journal of the American Medical Association. Vol. 128, Pg. 266, 1945.
dog LDLo parenteral 1gm/kg (1000mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Rassegna di Terapia e Patologia Clinica. Vol. 1, Pg. 472, 1929.
dog LDLo subcutaneous 1gm/kg (1000mg/kg) BRAIN AND COVERINGS: MENINGEAL CHANGES

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: NAUSEA OR VOMITING		 JAMA, Journal of the American Medical Association. Vol. 128, Pg. 266, 1945.
guinea pig LD50 subcutaneous 1200mg/kg (1200mg/kg) BEHAVIORAL: TREMOR

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING		 U.S. Army, Chemical Corps Medical Division Special Report. Vol. #2, Pg. 1950,
guinea pig LDLo oral 1gm/kg (1000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: OTHER CHANGES		 Revista de la Asociacion Medica Argentina. Vol. 46, Pg. 1493, 1932.
infant LDLo oral 934mg/kg (934mg/kg) ? JAMA, Journal of the American Medical Association. Vol. 90, Pg. 382, 1928.
infant LDLo skin 1200mg/kg (1200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"		 JAMA, Journal of the American Medical Association. Vol. 129, Pg. 332, 1945.
infant LDLo subcutaneous 1100mg/kg (1100mg/kg) BEHAVIORAL: TREMOR

GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"		 U.S. Army, Chemical Corps Medical Division Special Report. Vol. #2, Pg. 1950,
infant TDLo oral 800mg/kg/4W-I (800mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING		 Archives of Disease in Childhood. Vol. 58, Pg. 737, 1983.
man LDLo oral 429mg/kg (429mg/kg) CARDIAC: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"		 Journal of Toxicology, Clinical Toxicology. Vol. 31, Pg. 345, 1993.
man LDLo skin 2430mg/kg (2430mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

SKIN AND APPENDAGES (SKIN): PRIMARY IRRITATION: AFTER TOPICAL EXPOSURE		 JAMA, Journal of the American Medical Association. Vol. 128, Pg. 266, 1945.
man LDLo unreported 147mg/kg (147mg/kg) ? "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
man TDLo unreported 170mg/kg (170mg/kg) BEHAVIORAL: WAKEFULNESS

BEHAVIORAL: ANOREXIA (HUMAN

GASTROINTESTINAL: NAUSEA OR VOMITING		 Rassegna di Terapia e Patologia Clinica. Vol. 1, Pg. 472, 1929.
mouse LD50 intravenous 1240mg/kg (1240mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 117, 1961.
mouse LD50 oral 3450mg/kg (3450mg/kg) ? JAMA, Journal of the American Medical Association. Vol. 128, Pg. 266, 1945.
mouse LD50 subcutaneous 1740mg/kg (1740mg/kg) ? JAMA, Journal of the American Medical Association. Vol. 128, Pg. 266, 1945.
mouse LDLo intraperitoneal 800mg/kg (800mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA		 "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964.
rabbit LDLo intravenous 800mg/kg (800mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA		 "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964.
rabbit LDLo oral 4gm/kg (4000mg/kg) BEHAVIORAL: TREMOR

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING		 U.S. Army, Chemical Corps Medical Division Special Report. Vol. #2, Pg. 1950,
rabbit LDLo parenteral 670mg/kg (670mg/kg) ? Rassegna di Terapia e Patologia Clinica. Vol. 1, Pg. 472, 1929.
rabbit LDLo subcutaneous 150mg/kg (150mg/kg) ? "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
rat LCLo inhalation 28mg/m3/4H (28mg/m3) ? "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 27, 1982.
rat LD50 intravenous 1330mg/kg (1330mg/kg) BEHAVIORAL: TREMOR

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING		 U.S. Army, Chemical Corps Medical Division Special Report. Vol. #2, Pg. 1950,
rat LD50 oral 2660mg/kg (2660mg/kg) ? JAMA, Journal of the American Medical Association. Vol. 128, Pg. 266, 1945.
rat LD50 subcutaneous 1400mg/kg (1400mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA		 "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964.
women LDLo oral 200mg/kg (200mg/kg) BEHAVIORAL: FLUID INTAKE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING		 Lancet. Vol. 2, Pg. 162, 1917.
women TDLo oral 400mg/kg (400mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 32, Pg. 804, 1990.

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