4,4'-methylene-bis(2-chloroaniline) cas no:101-14-4
Synonyms: 4,4-Methylenebis(4-chloroaniline); 2,2-dichloro-4,4-methylenedianiline; ; 4,4-Methylene-Bis(Ortho-Chloroaniline); Bis-(4-Amino-2,3-dichlorophenyl)-methane; 4,4_-Methylen-bis-(2-chloranilin); 4,4'-Methylenebis-(2-chlroaniline); METHYLENE-BIS-ORTHOCHLOROANILINE; MOCA; 4,4'-Diamino-3,3'-dichlorodiphenylmethane; Sulfonating Agent MOCA
Name4,4'-methylene-bis(2-chloroaniline)
CAS101-14-4
Synonyms4,4-Methylenebis(4-chloroaniline); 2,2-dichloro-4,4-methylenedianiline; ; 4,4-Methylene-Bis(Ortho-Chloroaniline); Bis-(4-Amino-2,3-dichlorophenyl)-methane; 4,4_-Methylen-bis-(2-chloranilin); 4,4'-Methylenebis-(2-chlroaniline); METHYLENE-BIS-ORTHOCHLOROANILINE; MOCA; 4,4'-Diamino-3,3'-dichlorodiphenylmethane; Sulfonating Agent MOCA
EINECS(EC#)202-918-9
Molecular FormulaC13H12Cl2N2
Molecular Weight267.15
Appearanceoff-white powder with slight odor
refractive index1.671
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Hazard T:Toxic
Risk R22;R45;R50
Safety
Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by ingestion and intraperitoneal routes. Mutation data reported. Flammable liquid. Reactive with active metals such as sodium, potassium, magnesium, or zinc. When heated to decomposition it emits very toxic fumes of Cl? and NOx. See also AMINES.
Hazard Codes: 
T,
N
Risk Statements: 45-22-50/53-53-50
R45:May cause cancer.
R22:Harmful if swallowed.
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R53:May cause long-term adverse effects in the aquatic environment.
R50:Very toxic to aquatic organisms.
Safety Statements: 53-45-60-61
S53:Avoid exposure - obtain special instructions before use.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S60:This material and its container must be disposed of as hazardous waste.
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN 3077 9/PG 3
WGK Germany: 3
RTECS: CY1050000
HazardClass: 6.1(b)
PackingGroup: III
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| guinea pig |
LD50 |
oral |
400mg/kg (400mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: CYANOSIS |
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(6), Pg. 86, 1990. |
| mouse |
LD50 |
intraperitoneal |
64mg/kg (64mg/kg) |
|
Progress in Mutation Research. Vol. 1, Pg. 682, 1981. |
| mouse |
LD50 |
oral |
640mg/kg (640mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: CYANOSIS |
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(6), Pg. 86, 1990. |
| rabbit |
LD50 |
skin |
> 5gm/kg (5000mg/kg) |
|
"Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986Vol. 6, Pg. 988, 1991. |
| rat |
LD50 |
oral |
1140mg/kg (1140mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: CYANOSIS |
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(6), Pg. 86, 1990. |
| rat |
LD50 |
subcutaneous |
> 5gm/kg (5000mg/kg) |
|
Naturwissenschaften. Vol. 58, Pg. 578, 1971. |
| rat |
LDLo |
unreported |
1gm/kg (1000mg/kg) |
BEHAVIORAL: MUSCLE WEAKNESS
LUNGS, THORAX, OR RESPIRATION: CYANOSIS
KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED |
American Industrial Hygiene Association Journal. Vol. 32, Pg. 802, 1971. |
