101-26-8|MestinonProducts Supply - Chemical intermediates Network

Mestinon cas no:101-26-8

Synonyms: Pyridinium, 3-hydroxy-1-methyl-, bromide, dimethylcarbamate(8CI);Carbamic acid, dimethyl-, ester with 3-hydroxy-1-methylpyridiniumbromide (8CI);1-Methyl-3-hydroxypyridinium bromide dimethylcarbamate;3-(Dimethylcarbamoyloxy)-1-methylpyridinium bromide;3-(Dimethylcarbamyloxy)-1-methylpyridinium bromide;3-[[(Dimethylamino)carbonyl]oxy]-1-methylpyridinium bromide;Kalimin;Kalymin;3-Hydroxy-1-methylpyridiniumbromide, dimethylcarbamate (6CI,7CI);Pyridinium, 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-,bromide (9CI);

Identification

NameMestinon
CAS101-26-8
SynonymsPyridinium, 3-hydroxy-1-methyl-, bromide, dimethylcarbamate(8CI);Carbamic acid, dimethyl-, ester with 3-hydroxy-1-methylpyridiniumbromide (8CI);1-Methyl-3-hydroxypyridinium bromide dimethylcarbamate;3-(Dimethylcarbamoyloxy)-1-methylpyridinium bromide;3-(Dimethylcarbamyloxy)-1-methylpyridinium bromide;3-[[(Dimethylamino)carbonyl]oxy]-1-methylpyridinium bromide;Kalimin;Kalymin;3-Hydroxy-1-methylpyridiniumbromide, dimethylcarbamate (6CI,7CI);Pyridinium, 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-,bromide (9CI);
EINECS(EC#)202-929-9
Molecular FormulaC₉H₁₃BrN₂O₂
Molecular Weight261.11572

Chemical Properties

AppearancePale yellow to colorless liquid
refractive index1.48 (20 C)
storage tempKeep in a cool, dry location in a tightly closed container when not in use.

Safety Data

Hazard T+: Very toxic;
Risk R26/27/28
Safety

Safety Information about?Mestinon (CAS NO.101-26-8):
Hazard Codes:? Very T+
Risk Statements: 26/27/28-43
R26/27/28: Very toxic by inhalation, in contact with skin and if swallowed.?
R43: May cause sensitization by skin contact.
Safety Statements: 22-36/37/39-45
S22: Do not breathe dust.?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2811 6.1/PG 2
RTECS: UU5270000
Poison by ingestion, intramuscular, subcutaneous, intravenous and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Br^? and NO_x. See also CARBAMATES and ESTERS.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	9mg/kg (9mg/kg)	PERIPHERAL NERVE AND SENSATION: FASCICULATIONS	Israel Journal of Medical Sciences. Vol. 27, Pg. 659, 1991.
mouse	LD50	intraperitoneal	1mg/kg (1mg/kg)	?	Drugs in Japan Vol. 6, Pg. 354, 1982.
mouse	LD50	intravenous	1500ug/kg (1.5mg/kg)	?	Medicinal Chemistry, A Series of Reviews. Vol. 3, Pg. 329, 1956.
mouse	LD50	oral	16mg/kg (16mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Gendai no Rinsho. Vol. 2, Pg. 828, 1968.
mouse	LD50	subcutaneous	1500ug/kg (1.5mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Gendai no Rinsho. Vol. 2, Pg. 828, 1968.
rat	LD50	intramuscular	2790ug/kg (2.79mg/kg)	?	Drug and Chemical Toxicology. Vol. 7, Pg. 507, 1984.
rat	LD50	intraperitoneal	2699ug/kg (2.699mg/kg)	?	Fundamental and Applied Toxicology. Vol. 4, Pg. S195, 1984.
rat	LD50	oral	37500ug/kg (37.5mg/kg)	?	Drugs in Japan Vol. -, Pg. 1042, 1995.
rat	LD50	subcutaneous	3100ug/kg (3.1mg/kg)	?	Journal of Medicinal Chemistry. Vol. 26, Pg. 145, 1983.
women	TDLo	oral	7800ug/kg (7.8mg/kg)	PERIPHERAL NERVE AND SENSATION: FASCICULATIONS SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE GASTROINTESTINAL: NAUSEA OR VOMITING	Israel Journal of Medical Sciences. Vol. 27, Pg. 659, 1991.

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Mestinon cas no:101-26-8

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