10118-90-8|2-Naphthacenecarboxamide,4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,(4S,4aS,5aR,12aS)-Products Supply

2-Naphthacenecarboxamide,4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,(4S,4aS,5aR,12aS)- cas no:10118-90-8

Synonyms: 2-Naphthacenecarboxamide,4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-(8CI);2-Naphthacenecarboxamide,4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,[4S-(4a,4aa,5aa,12aa)]-;CL 59806;Dynacin;Minocyclin;Minocyn;Tri-minocycline;

Identification

Name2-Naphthacenecarboxamide,4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,(4S,4aS,5aR,12aS)-
CAS10118-90-8
Synonyms2-Naphthacenecarboxamide,4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-(8CI);2-Naphthacenecarboxamide,4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,[4S-(4a,4aa,5aa,12aa)]-;CL 59806;Dynacin;Minocyclin;Minocyn;Tri-minocycline;
EINECS(EC#)237-099-7
Molecular FormulaC₂₃H₂₇N₃O₇
Molecular Weight457.48

Chemical Properties

AppearanceBright yellow-orange amorphous solid.
refractive index1.717
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Safety Data

Safety

Poison by intraperitoneal, intravenous, and intracerebral routes. Moderately toxic by ingestion. Human systemic effects by ingestion: interstitial nephritis, proteinuris and hematuris. Human mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
infant	TDLo	oral	12mg/kg/2D-I (12mg/kg)	BRAIN AND COVERINGS: INCREASED INTRACRANIAL PRESSURE GASTROINTESTINAL: NAUSEA OR VOMITING	Therapie. Vol. 38, Pg. 93, 1983.
man	TDLo	oral	343mg/kg/17W- (343mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" LIVER: LIVER FUNCTION TESTS IMPAIRED BLOOD: EOSINOPHILIA	American Journal of Gastroenterology. Vol. 91, Pg. 1641, 1996.
mouse	LD50	intracrebral	38mg/kg (38mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: EXCITEMENT MUSCULOSKELETAL: CHANGES IN TEETH AND SUPPORTING STRUCTURES	Chemotherapy Vol. 26, Pg. 196, 1980.
mouse	LD50	intraperitoneal	310mg/kg (310mg/kg)		"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 501, 1978.
mouse	LD50	intravenous	140mg/kg (140mg/kg)		"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 501, 1978.
mouse	LD50	oral	3100mg/kg (3100mg/kg)		"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 501, 1978.
women	TDLo	oral	8mg/kg (8mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"	American Journal of Medicine. Vol. 109, Pg. 340, 2000.
women	TDLo	oral	28mg/kg/2W-I (28mg/kg)	BRAIN AND COVERINGS: "CHANGES IN CIRCULATION (HEMORRHAGE, THROMBOSIS, ETC.)" BEHAVIORAL: HEADACHE SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE	Annals of Internal Medicine. Vol. 127, Pg. 168, 1997.
women	TDLo	oral	100mg/kg (100mg/kg)	KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS KIDNEY, URETER, AND BLADDER: HEMATURIA KIDNEY, URETER, AND BLADDER: PROTEINURIS	British Medical Journal. Vol. 1, Pg. 524, 1979.
women	TDLo	oral	112mg/kg/4W-I (112mg/kg)	LIVER: LIVER FUNCTION TESTS IMPAIRED SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	American Journal of Gastroenterology. Vol. 91, Pg. 1641, 1996.
women	TDLo	oral	730mg/kg/1Y-I (730mg/kg)	BEHAVIORAL: ANOREXIA (HUMAN GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: LIVER FUNCTION TESTS IMPAIRED	American Journal of Gastroenterology. Vol. 91, Pg. 1641, 1996.
women	TDLo	oral	1204mg/kg/86W (1204mg/kg)	MUSCULOSKELETAL: JOINTS	British Journal of Rheumatology. Vol. 33, Pg. 674, 1994.
women	TDLo	oral	17520mg/kg/12 (17520mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE MUSCULOSKELETAL: CHANGES IN TEETH AND SUPPORTING STRUCTURES SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	American Journal of Ophthalmology. Vol. 125, Pg. 396, 1998.

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2-Naphthacenecarboxamide,4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,(4S,4aS,5aR,12aS)- cas no:10118-90-8

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