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Lomerizine dihydrochloride cas no:101477-54-7

Synonyms: Piperazine,1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-,dihydrochloride (9CI);1-(2,3,4-Trimethoxybenzyl)-4-(bis(4-fluorophenyl)methyl)piperazine dihydrochloride;1-(Bis(4-fluorophenyl)methyl)-4-((2,3,4-trimethoxyphenyl)methyl)piperazine dihydrochloride;Lomerizinehydrochloride;Lomerizine HCl;

Identification
NameLomerizine dihydrochloride
CAS101477-54-7
SynonymsPiperazine,1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-,dihydrochloride (9CI);1-(2,3,4-Trimethoxybenzyl)-4-(bis(4-fluorophenyl)methyl)piperazine dihydrochloride;1-(Bis(4-fluorophenyl)methyl)-4-((2,3,4-trimethoxyphenyl)methyl)piperazine dihydrochloride;Lomerizinehydrochloride;Lomerizine HCl;
Molecular FormulaC27H32Cl2F2N2O3
Molecular Weight541.46
Chemical Properties
Appearancecolourless crystalline solid
Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 706mg/kg (706mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Cardiovascular Drug Reviews. Vol. 8, Pg. 105, 1990.
mouse LD50 intravenous 44mg/kg (44mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Cardiovascular Drug Reviews. Vol. 8, Pg. 105, 1990.
mouse LD50 oral 300mg/kg (300mg/kg)   European Patent Application. Vol. #159566,
mouse LD50 subcutaneous > 1200mg/kg (1200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Cardiovascular Drug Reviews. Vol. 8, Pg. 105, 1990.
rat LD50 intravenous 27mg/kg (27mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Cardiovascular Drug Reviews. Vol. 8, Pg. 105, 1990.
rat LD50 oral 307mg/kg (307mg/kg)   Cardiovascular Drug Reviews. Vol. 8, Pg. 105, 1990.
rat LD50 subcutaneous 882mg/kg (882mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Cardiovascular Drug Reviews. Vol. 8, Pg. 105, 1990.

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Wuhan Pharma Chemical Co., Ltd.
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Yancheng Luye Chemical Co.,Ltd.
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Taizhou Ingore Bio & Tech Co., Ltd.
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NEW FORTUNE INDUSTRIAL CO.,LTD.
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AOPHARM
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Hebei yanxi chemical co., LTD
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Nanjing Bangnuo Biotechnology Co., Ltd
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Hubei XinRunde Chemical Co., Ltd
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Shanghai Do Chemical Co.,Ltd
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Address: No 350,Guoshoujing Road, Zhangjiang Hi-tech Park, Pudong, Shanghai, China
Hangzhou J&H Chemical Co., Ltd
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Wuhan Senwayer Century chemical Co.,Ltd
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Address: 20#Xudong Street,Wuhan China
Hangzhou Dayangchem Co., Ltd.
Tel:86-571-88938639
Address: 9/F Unit 2 ChangdiTorch Building, 259 #WenSan Road
Finetech Industry limited.
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Boc Sciences
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Address: 45-16 Ramsey Road, Shirley, NY 11967, USA
Wuhan Fortuna Chemical Co., Ltd.
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Address: A2705,Dong Yi Shi Qu,129# XinHua Road

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