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Lomerizine dihydrochloride cas no:101477-54-7

Synonyms: Piperazine,1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-,dihydrochloride (9CI);1-(2,3,4-Trimethoxybenzyl)-4-(bis(4-fluorophenyl)methyl)piperazine dihydrochloride;1-(Bis(4-fluorophenyl)methyl)-4-((2,3,4-trimethoxyphenyl)methyl)piperazine dihydrochloride;Lomerizinehydrochloride;Lomerizine HCl;

Identification
NameLomerizine dihydrochloride
CAS101477-54-7
SynonymsPiperazine,1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-,dihydrochloride (9CI);1-(2,3,4-Trimethoxybenzyl)-4-(bis(4-fluorophenyl)methyl)piperazine dihydrochloride;1-(Bis(4-fluorophenyl)methyl)-4-((2,3,4-trimethoxyphenyl)methyl)piperazine dihydrochloride;Lomerizinehydrochloride;Lomerizine HCl;
Molecular FormulaC27H32Cl2F2N2O3
Molecular Weight541.46
Chemical Properties
Appearancecolourless crystalline solid
Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 706mg/kg (706mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Cardiovascular Drug Reviews. Vol. 8, Pg. 105, 1990.
mouse LD50 intravenous 44mg/kg (44mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Cardiovascular Drug Reviews. Vol. 8, Pg. 105, 1990.
mouse LD50 oral 300mg/kg (300mg/kg)   European Patent Application. Vol. #159566,
mouse LD50 subcutaneous > 1200mg/kg (1200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Cardiovascular Drug Reviews. Vol. 8, Pg. 105, 1990.
rat LD50 intravenous 27mg/kg (27mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Cardiovascular Drug Reviews. Vol. 8, Pg. 105, 1990.
rat LD50 oral 307mg/kg (307mg/kg)   Cardiovascular Drug Reviews. Vol. 8, Pg. 105, 1990.
rat LD50 subcutaneous 882mg/kg (882mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Cardiovascular Drug Reviews. Vol. 8, Pg. 105, 1990.

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Tianjin Harmony Technology Development Co., Ltd.
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Ontario Chemicals, Inc.
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Suzhou Kaiyuan Minsheng Chemicals Technology Co., Ltd.
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Wuhan Pharma Chemical Co., Ltd.
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Yancheng Luye Chemical Co.,Ltd.
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Address: Longgang Chemical Zone, Yancheng, Jiangsu Province 224011,
Taizhou Ingore Bio & Tech Co., Ltd.
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Address: Huatao, Tiantai County, Taizhou, Zhejiang 317207,
Beijing Nordhuns Chemical Technology Co., Ltd.
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Address: 202 Xinhengji Office Building, No.66 Beiyuan Road, Chaoyang, beijing,
Shanghai Fortune Bio-Technology Co., Ltd.
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Address: Hu Min Rd.,Minhang District, Shanghai,
Shandong Zhongke Taidou Chemical Co., Ltd.
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Address: Hongyuan Development Park, Jinan, Shandong 250100,
Ji'nan Zhongke Yitong Chemical Co.,Ltd.
Tel:+86-(531)-8865-8009
Address: No.106 Industry South Road, Jinan, Shandong 250100,
Taizhou Crene Chempharm Co., Ltd.
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Address: Weiwu Load Economic Developed Zone, Taizhou, Zhejiang 318000,
Beijing Huikang Boyuan Chemical Tech Co.,LTD
Tel:+86-10-68862197,68867502
Address: No.7 Haiying Road,Science City,Fengtai District,Beijing,China
Beijing Hengrun Weiyuan Biotechnologies,. Inc.
Tel:+86-(10)-6969-6397
Address: Room A624, No.58 Liangguan Road, Fangshan District, Beijing 102000,
Beijing Team Academy of Pharmaceutical Sciences Co., Ltd
Tel:86-10-68180921 , 13501010127,13911611675
Address: No. 329,Jiangjiafen Road, Fengtai District, Beijing, P.R.China
Beijing HuameiHuli Biochem Ltd
Tel:010-86181995
Address: Beijing TongZhou District

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