dog |
LDLo |
subcutaneous |
2gm/kg (2000mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LIVER: OTHER CHANGES
BLOOD: NORMOCYTIC ANEMIA |
Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 137, 1992. |
mouse |
LD |
subcutaneous |
> 5gm/kg (5000mg/kg) |
|
Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 195, 1992. |
mouse |
LD50 |
intraperitoneal |
1743mg/kg (1743mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 195, 1992. |
mouse |
LD50 |
oral |
2715mg/kg (2715mg/kg) |
AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 195, 1992. |
rat |
LD |
skin |
> 5gm/kg (5000mg/kg) |
|
Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 195, 1992. |
rat |
LD |
subcutaneous |
> 5gm/kg (5000mg/kg) |
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 195, 1992. |
rat |
LD50 |
intraperitoneal |
1655mg/kg (1655mg/kg) |
AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
BEHAVIORAL: REGIDITY |
Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 195, 1992. |
rat |
LD50 |
oral |
652mg/kg (652mg/kg) |
AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 195, 1992. |