103-90-2|4-AcetamidophenolProducts Supply - Chemical intermediates Network

4-Acetamidophenol cas no:103-90-2

Synonyms: Acetaminophen; 4-Hydroxyacetanilide; Paracetamol; APAP; p-Hydroxyacetanilide; Paracetamol ; 4-Acetamino phenol; Acetaminphen;

Identification

Name4-Acetamidophenol
CAS103-90-2
SynonymsAcetaminophen; 4-Hydroxyacetanilide; Paracetamol; APAP; p-Hydroxyacetanilide; Paracetamol ; 4-Acetamino phenol; Acetaminphen;
EINECS(EC#)203-157-5
Molecular FormulaC8H9NO2
Molecular Weight151.16

Chemical Properties

Appearancewhite crystalline powder
refractive index1.619
storage tempStore in a cool, dry place. Keep container closed when not in use.

Safety Data

Hazard Xn:Harmful
Risk R22;R36/38;R52/53
Safety

Hazard Codes of Paracetamol (CAS NO.103-90-2):? Harmful Xn
Risk Statements: 22-36/37/38-52/53-40?
R22: 3Harmful if swallowed.?
R36/37/38: Irritating to eyes, respiratory system and skin.?
R52/53: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.?
R40: Limited evidence of a carcinogenic effect.
Safety Statements: 26-36-61-37/39-22?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36: Wear suitable protective clothing.?
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.?
S37/39: Wear suitable gloves and eye/face protection.?
S22: Do not breathe dust.
WGK Germany: 1
RTECS: AE4200000
HS Code:?29242930

HS Code 29242930

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	LDLo	oral	50mg/kg (50mg/kg)	CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	American Journal of Emergency Medicine. Vol. 6, Pg. 510, 1988.
child	LDLo	oral	140mg/kg/7D-I (140mg/kg)	BEHAVIORAL: COMA LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"	Medical Journal of Australia. Vol. 171, Pg. 472, 1999.
child	LDLo	oral	360mg/kg/2D (360mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Journal of Pediatrics. Vol. 92, Pg. 832, 1978.
child	TDLo	oral	591mg/kg/2D-I (591mg/kg)	LIVER: LIVER FUNCTION TESTS IMPAIRED KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" BLOOD: APLASTIC ANEMIA	Clinical Pediatrics Vol. 33, Pg. 42, 1994.
child	TDLo	oral	801mg/kg (801mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: OTHER CHANGES	Pediatrics. Vol. 61, Pg. 68, 1978.
dog	LDLo	intravenous	826mg/kg (826mg/kg)	BEHAVIORAL: ANALGESIA	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964.
dog	LDLo	oral	2gm/kg (2000mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BLOOD: CHANGES IN SPLEEN	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 24, Pg. 602, 1993.
frog	LDLo	subcutaneous	50mg/kg (50mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: ATAXIA	Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 33, Pg. 216, 1894.
guinea pig	LD50	oral	2620mg/kg (2620mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958.
human	LDLo	oral	143mg/kg (143mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC	British Medical Journal. Vol. 282, Pg. 199, 1981.
human	LDLo	oral	357mg/kg (357mg/kg)	BEHAVIORAL: ANOREXIA (HUMAN GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: COMA	Lancet. Vol. 1, Pg. 66, 1973.
infant	TDLo	oral	1440mg/kg/6D (1440mg/kg)	BEHAVIORAL: IRRITABILITY GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	American Journal of Diseases of Children. Vol. 137, Pg. 386, 1983.
mammal (species unspecified)	LD50	unreported	891mg/kg (891mg/kg)	?	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(6), Pg. 22, 1983.
mammal (species unspecified)	LDLo	oral	512mg/kg (512mg/kg)	?	United States Patent Document. Vol. #4035499,
man	LDLo	oral	143mg/kg/24H- (143mg/kg)	BEHAVIORAL: ANOREXIA (HUMAN LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"	American Journal of Medicine. Vol. 74, Pg. 349, 1983.
man	LDLo	oral	714mg/kg (714mg/kg)	LIVER: OTHER CHANGES	Human Toxicology. Vol. 1, Pg. 25, 1981.
man	TDLo	oral	9286ug/kg (9.286mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE SENSE ORGANS AND SPECIAL SENSES: OTHER: EAR SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Allergy. Vol. 50(Suppl,
man	TDLo	oral	714mg/kg (714mg/kg)	CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE	Postgraduate Medical Journal. Vol. 69, Pg. 52, 1993.
mouse	LD50	intraperitoneal	367mg/kg (367mg/kg)	BEHAVIORAL: ANALGESIA	Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 520, 1965.
mouse	LD50	oral	338mg/kg (338mg/kg)	?	Toxicology and Applied Pharmacology. Vol. 19, Pg. 20, 1971.
mouse	LD50	subcutaneous	310mg/kg (310mg/kg)	?	Human Toxicology. Vol. 3, Pg. 13S, 1984.
pig	LDLo	intravenous	1gm/kg (1000mg/kg)	LIVER: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Veterinary and Human Toxicology. Vol. 30, Pg. 324, 1988.
rat	LD50	intraperitoneal	1205mg/kg (1205mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR	Studi Sassaresi, Sezione 2. Vol. 57, Pg. 561, 1979.
rat	LD50	oral	1944mg/kg (1944mg/kg)	?	United States Patent Document. Vol. #4636513,
women	LDLo	oral	260mg/kg (260mg/kg)	BEHAVIORAL: COMA GASTROINTESTINAL: NAUSEA OR VOMITING KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	JAMA, Journal of the American Medical Association. Vol. 236, Pg. 1874, 1976.
women	LDLo	oral	400mg/kg (400mg/kg)	BEHAVIORAL: COMA LIVER: LIVER FUNCTION TESTS IMPAIRED	Journal of Toxicology, Clinical Toxicology. Vol. 35, Pg. 325, 1997.
women	LDLo	oral	650mg/kg (650mg/kg)	VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION VASCULAR: OTHER CHANGES	American Journal of Emergency Medicine. Vol. 6, Pg. 511, 1988.
women	TDLo	oral	4962ug/kg (4.962mg/kg)	GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS BLOOD: OTHER CHANGES LIVER: LIVER FUNCTION TESTS IMPAIRED	Journal of Toxicology, Clinical Toxicology. Vol. 29, Pg. 223, 1991. Link to PubMed
women	TDLo	oral	13mg/kg (13mg/kg)	BEHAVIORAL: EXCITEMENT	Allergy. Vol. 50(Suppl,
women	TDLo	oral	325mg/kg (325mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	Postgraduate Medical Journal. Vol. 68, Pg. 116, 1992.
women	TDLo	oral	490mg/kg (490mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Southern Medical Journal. Vol. 71, Pg. 906, 1978.

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4-Acetamidophenol cas no:103-90-2

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