Estra-1,3,5(10)-trien-17-ol,3-methoxy-, (17b)- cas no:1035-77-4

NameEstra-1,3,5(10)-trien-17-ol,3-methoxy-, (17b)-
CAS1035-77-4
SynonymsEstra-1,3,5(10)-trien-17b-ol, 3-methoxy- (6CI,8CI); 17b-Estradiol 3-methyl ether; 17b-Hydroxy-3-methoxyestra-1,3,5(10)-triene;3-Methoxy-13b-methyl-1,3,5(10)-gonatrien-17b-ol; 3-Methoxy-17b-hydroxyestra-1,3,5(10)-triene;3-Methoxyestra-1,3,5(10)-trien-17b-ol; 3-Methoxyestra-1,3,5(10)-triene-17b-ol; 3-Methoxyestra-1,3,5(10)-triene-3,17b-diol; 3-Methoxyestradiol; 3-Methoxyoestra-1,3,5(10)-trien-17b-ol; 3-O-Methylestradiol;Estradiol 3-methyl ether; NSC 58851
EINECS(EC#)213-858-8
Molecular FormulaC19H26 O2
Molecular Weight286.45

refractive index1.566

Safety Experimental reproductive effects. A steroid. When heated to decomposition it emits acrid smoke and irritating fumes.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

KG7732000

CHEMICAL NAME :

Estra-1,3,5(10)-trien-17-beta-ol, 3-methoxy-

CAS REGISTRY NUMBER :

1035-77-4

LAST UPDATED :

198910

DATA ITEMS CITED :

5

MOLECULAR FORMULA :

C19-H26-O2

MOLECULAR WEIGHT :

286.45

WISWESSER LINE NOTATION :

L E5 B666TTT&J E1 FQ OO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

2 mg/kg

SEX/DURATION :

male 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :

ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 49,193,1965

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

2500 ug/kg

SEX/DURATION :

female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Fertility - other measures of fertility

REFERENCE :

ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 49,193,1965

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

132 ug/kg

SEX/DURATION :

female 3 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - other measures of fertility

REFERENCE :

ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 47,444,1964

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

1050 ug/kg

SEX/DURATION :

female 3-9 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :

ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 47,444,1964

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

3 mg/kg

SEX/DURATION :

female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - other measures of fertility

REFERENCE :

85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press, 1965 Volume(issue)/page/year: -,57,1965