| man |
TDLo |
subcutaneous |
429ug/kg/2W-I (0.429mg/kg) |
BEHAVIORAL: MUSCLE WEAKNESS |
Lancet. Vol. 341, Pg. 1091, 1993. |
| man |
TDLo |
subcutaneous |
86mg/kg (86mg/kg) |
CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE |
British Medical Journal. Vol. 304, Pg. 1415, 1992. |
| mouse |
LDLo |
oral |
> 500mg/kg (500mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
BEHAVIORAL: ATAXIA |
Human & Experimental Toxicology. Vol. 14, Pg. 959, 1995. |
| mouse |
LDLo |
subcutaneous |
> 100mg/kg (100mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS |
Human & Experimental Toxicology. Vol. 14, Pg. 959, 1995. |
| rat |
LD |
intravenous |
> 20mg/kg (20mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Human & Experimental Toxicology. Vol. 14, Pg. 959, 1995. |
| rat |
LD |
subcutaneous |
> 1gm/kg (1000mg/kg) |
BEHAVIORAL: TREMOR
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Human & Experimental Toxicology. Vol. 14, Pg. 959, 1995. |
| rat |
LDLo |
oral |
> 2gm/kg (2000mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
BEHAVIORAL: ATAXIA |
Human & Experimental Toxicology. Vol. 14, Pg. 959, 1995. |
| women |
TDLo |
subcutaneous |
120ug/kg (0.12mg/kg) |
BEHAVIORAL: MUSCLE WEAKNESS |
Lancet. Vol. 341, Pg. 1091, 1993. |
| women |
TDLo |
subcutaneous |
120ug/kg (0.12mg/kg) |
CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE
GASTROINTESTINAL: NAUSEA OR VOMITING
CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP |
Annals of Internal Medicine. Vol. 129, Pg. 874, 1998. |
| women |
TDLo |
subcutaneous |
240ug/kg/1H-I (0.24mg/kg) |
PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" |
Lancet. Vol. 343, Pg. 1105, 1994. |
