103628-46-2|1H-Indole-5-methanesulfonamide,3-[2-(dimethylamino)ethyl]-N-methyl-Products Supply

1H-Indole-5-methanesulfonamide,3-[2-(dimethylamino)ethyl]-N-methyl- cas no:103628-46-2

Synonyms: 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide;GR 43175;GR 43175X;Alsuma;BRN 6930870;Sumatriptanum;UNII-8R78F6L9VO;1H-Indole-5-methanesulfonamide, 3-(2-(dimethylamino)ethyl)-N-methyl-;

Identification

Name1H-Indole-5-methanesulfonamide,3-[2-(dimethylamino)ethyl]-N-methyl-
CAS103628-46-2
Synonyms3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide;GR 43175;GR 43175X;Alsuma;BRN 6930870;Sumatriptanum;UNII-8R78F6L9VO;1H-Indole-5-methanesulfonamide, 3-(2-(dimethylamino)ethyl)-N-methyl-;
Molecular FormulaC₁₄H₂₁N₃O₂S
Molecular Weight295.4

Chemical Properties

AppearanceWhite to off-white crystalline powder
refractive index1.595
storage tempNo storage requirements necessary for occupational hazards. Follow product information storage instructions to maintain efficacy.

Safety Data

Hazard UN NO.
Risk R36/37/38
Safety

A poison by subcutaneous route. Moderately toxic by ingestion. Questionable carcinogen with experimental carcinogenic data. Human systemic effecte: cardiac arrhythmias, EKG changes, muscle weakness, sensory change involving peripheral nerve, flaccid paralysis without anesthesia, hallucinations, distorted perceptions. When heated to decomposition it emits toxic vapors of NO_x and SO_x.
Hazard Codes:Xi
Risk Statements:36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements:26
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RTECS:NL9482200

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	subcutaneous	429ug/kg/2W-I (0.429mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS	Lancet. Vol. 341, Pg. 1091, 1993.
man	TDLo	subcutaneous	86mg/kg (86mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE	British Medical Journal. Vol. 304, Pg. 1415, 1992.
mouse	LDLo	oral	> 500mg/kg (500mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" BEHAVIORAL: ATAXIA	Human & Experimental Toxicology. Vol. 14, Pg. 959, 1995.
mouse	LDLo	subcutaneous	> 100mg/kg (100mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Human & Experimental Toxicology. Vol. 14, Pg. 959, 1995.
rat	LD	intravenous	> 20mg/kg (20mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Human & Experimental Toxicology. Vol. 14, Pg. 959, 1995.
rat	LD	subcutaneous	> 1gm/kg (1000mg/kg)	BEHAVIORAL: TREMOR SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Human & Experimental Toxicology. Vol. 14, Pg. 959, 1995.
rat	LDLo	oral	> 2gm/kg (2000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" BEHAVIORAL: ATAXIA	Human & Experimental Toxicology. Vol. 14, Pg. 959, 1995.
women	TDLo	subcutaneous	120ug/kg (0.12mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS	Lancet. Vol. 341, Pg. 1091, 1993.
women	TDLo	subcutaneous	120ug/kg (0.12mg/kg)	CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE GASTROINTESTINAL: NAUSEA OR VOMITING CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	Annals of Internal Medicine. Vol. 129, Pg. 874, 1998.
women	TDLo	subcutaneous	240ug/kg/1H-I (0.24mg/kg)	PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	Lancet. Vol. 343, Pg. 1105, 1994.

supplier list

Zhejiang Medicines & Health Products Import & Exp...: Tel:; Address: ZMC Building,101-2 N. Zhongshan Road,Hangzhou,China.

Beijing Lunarsun Pharmaceutical Co.Ltd.: Tel:086-10-81760039 80771377 80771378 80771379 81760170 81760171 81760172; Address: C1-802, Yangguangguangchang, Anli Road No.68 ,Chaoyang District , 100101 , Beijing , P.R.China

Apeloa Co., Ltd.: Tel:; Address: 11F, 18, Moganshan Road, Hangzhou City, Zhejiang Province,China (Marketing & Sales)

Melone Pharmaceutical Co., Ltd.: Tel:; Address: Room 2209锛孨o.232, Jinma Road, Development Zone, Dalian, China

Hangzhou Polychem Co., Ltd.: Tel:; Address: 16/F, Unit 2, Dikai Mansion, 471 Jincheng Rd., Xiaoshan Dist., Hangzhou, Zhejiang, China.

Beijing Kaida Technology Development Co., Ltd.: Tel:+86-(010)-62993416; Address: Science and Technology Park, Changping, Beijing torch on the 21st Street, Changping, Beijing 102200,

Tecoland Corporation: Tel:+1-(732)-603-9577; Address: 100 Menlo Park Drive, Suite 316, Edison, New Jersey 08837-2428,

Nanjing Hicin Pharmaceutical Co., Ltd.: Tel:+86-(25)-83241000; Address: 70# Matai Street, Nanjing, Jiangsu 210009,

Beijing Lianben Pharm-Chemicals Tech. Co., Ltd.: Tel:+86-(10)-8338-6766; Address: No 406 Xinzhuang, Changxindian, Fengtai District, Beijing 100074,

Taizhou Xingcheng Chempharm Co., Ltd.: Tel:+86-(576)-88886292, 88525005; Address: B Area. 10 Floor.Yaodadasha. 289#.Shifu Road, Taizhou, Zhejiang 318000,

Xilin Chemical Group Co., Ltd: Tel:+86-(0)-15527136576; Address: 16# Luojiashan, Wuchang District, Wuhan, Hubei 430071,

EASYBUYER LTD.,: Tel:+86-21-35015877 +86-13701868511; Address: Room 407, Building 10, Hi-Shanghai Center, No.990 Dalian Rd,Shanghai 200092 China

Shanghai Xunxin Chemical Co., Ltd: Tel:+86-(21)-38218795; Address: 580 Lane, Kanghong Road, Pudong New District, Shanghai 201315,

Synthetics China Co., Ltd.: Tel:+86-(523)-8798-0162; Address: Qiwei Town, Taixing, Jiangsu 225453,

zhejiang hengdian import and export co., ltd: Tel:+86-571-87635726; Address: 3f, world trade center wtcz, 122shuguang rd, hangzhou, china

1H-Indole-5-methanesulfonamide,3-[2-(dimethylamino)ethyl]-N-methyl- cas no:103628-46-2

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