103628-46-2|1H-Indole-5-methanesulfonamide,3-[2-(dimethylamino)ethyl]-N-methyl-Products Supply

1H-Indole-5-methanesulfonamide,3-[2-(dimethylamino)ethyl]-N-methyl- cas no:103628-46-2

Synonyms: 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide;GR 43175;GR 43175X;Alsuma;BRN 6930870;Sumatriptanum;UNII-8R78F6L9VO;1H-Indole-5-methanesulfonamide, 3-(2-(dimethylamino)ethyl)-N-methyl-;

Identification

Name1H-Indole-5-methanesulfonamide,3-[2-(dimethylamino)ethyl]-N-methyl-
CAS103628-46-2
Synonyms3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide;GR 43175;GR 43175X;Alsuma;BRN 6930870;Sumatriptanum;UNII-8R78F6L9VO;1H-Indole-5-methanesulfonamide, 3-(2-(dimethylamino)ethyl)-N-methyl-;
Molecular FormulaC₁₄H₂₁N₃O₂S
Molecular Weight295.4

Chemical Properties

AppearanceWhite to off-white crystalline powder
refractive index1.595
storage tempNo storage requirements necessary for occupational hazards. Follow product information storage instructions to maintain efficacy.

Safety Data

Hazard UN NO.
Risk R36/37/38
Safety

A poison by subcutaneous route. Moderately toxic by ingestion. Questionable carcinogen with experimental carcinogenic data. Human systemic effecte: cardiac arrhythmias, EKG changes, muscle weakness, sensory change involving peripheral nerve, flaccid paralysis without anesthesia, hallucinations, distorted perceptions. When heated to decomposition it emits toxic vapors of NO_x and SO_x.
Hazard Codes:Xi
Risk Statements:36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements:26
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RTECS:NL9482200

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	subcutaneous	429ug/kg/2W-I (0.429mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS	Lancet. Vol. 341, Pg. 1091, 1993.
man	TDLo	subcutaneous	86mg/kg (86mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE	British Medical Journal. Vol. 304, Pg. 1415, 1992.
mouse	LDLo	oral	> 500mg/kg (500mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" BEHAVIORAL: ATAXIA	Human & Experimental Toxicology. Vol. 14, Pg. 959, 1995.
mouse	LDLo	subcutaneous	> 100mg/kg (100mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Human & Experimental Toxicology. Vol. 14, Pg. 959, 1995.
rat	LD	intravenous	> 20mg/kg (20mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Human & Experimental Toxicology. Vol. 14, Pg. 959, 1995.
rat	LD	subcutaneous	> 1gm/kg (1000mg/kg)	BEHAVIORAL: TREMOR SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Human & Experimental Toxicology. Vol. 14, Pg. 959, 1995.
rat	LDLo	oral	> 2gm/kg (2000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" BEHAVIORAL: ATAXIA	Human & Experimental Toxicology. Vol. 14, Pg. 959, 1995.
women	TDLo	subcutaneous	120ug/kg (0.12mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS	Lancet. Vol. 341, Pg. 1091, 1993.
women	TDLo	subcutaneous	120ug/kg (0.12mg/kg)	CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE GASTROINTESTINAL: NAUSEA OR VOMITING CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	Annals of Internal Medicine. Vol. 129, Pg. 874, 1998.
women	TDLo	subcutaneous	240ug/kg/1H-I (0.24mg/kg)	PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	Lancet. Vol. 343, Pg. 1105, 1994.

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1H-Indole-5-methanesulfonamide,3-[2-(dimethylamino)ethyl]-N-methyl- cas no:103628-46-2

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