Lacidipine cas no:103890-78-4
Synonyms: 3,5-Pyridinedicarboxylicacid,4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-,3,5-diethyl ester;3,5-Pyridinedicarboxylicacid,4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-,diethyl ester (9CI);3,5-Pyridinedicarboxylic acid,4-[2-[3-(1,1-dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-,diethyl ester, (E)-;Lacimen;Lacipil;Lacirex;Midotens;Motens;
NameLacidipine
CAS103890-78-4
Synonyms3,5-Pyridinedicarboxylicacid,4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-,3,5-diethyl ester;3,5-Pyridinedicarboxylicacid,4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-,diethyl ester (9CI);3,5-Pyridinedicarboxylic acid,4-[2-[3-(1,1-dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-,diethyl ester, (E)-;Lacimen;Lacipil;Lacirex;Midotens;Motens;
Molecular FormulaC26H33NO6
Molecular Weight455.55
AppearanceWhite-to-Off-White Crystalline Solid
refractive index1.54
storage tempStore in original container in a cool dark place.
Risk R20/21/22
Safety
Risk Codes: R20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.?
Safety Description: S36/37
S36/37:Wear suitable protective clothing and gloves.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD50 |
intraperitoneal |
80200ug/kg (80.2mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 335, 1994. |
| mouse |
LD50 |
oral |
3150mg/kg (3150mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 335, 1994. |
| mouse |
LD50 |
subcutaneous |
> 5gm/kg (5000mg/kg) |
? |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 335, 1994. |
| rat |
LD50 |
intraperitoneal |
43300ug/kg (43.3mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 335, 1994. |
| rat |
LD50 |
oral |
880mg/kg (880mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
KIDNEY, URETER, AND BLADDER: OTHER CHANGES |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 335, 1994. |
| rat |
LD50 |
subcutaneous |
562mg/kg (562mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
KIDNEY, URETER, AND BLADDER: OTHER CHANGES |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 335, 1994 |
