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Lacidipine cas no:103890-78-4

Synonyms: 3,5-Pyridinedicarboxylicacid,4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-,3,5-diethyl ester;3,5-Pyridinedicarboxylicacid,4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-,diethyl ester (9CI);3,5-Pyridinedicarboxylic acid,4-[2-[3-(1,1-dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-,diethyl ester, (E)-;Lacimen;Lacipil;Lacirex;Midotens;Motens;

Identification
NameLacidipine
CAS103890-78-4
Synonyms3,5-Pyridinedicarboxylicacid,4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-,3,5-diethyl ester;3,5-Pyridinedicarboxylicacid,4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-,diethyl ester (9CI);3,5-Pyridinedicarboxylic acid,4-[2-[3-(1,1-dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-,diethyl ester, (E)-;Lacimen;Lacipil;Lacirex;Midotens;Motens;
Molecular FormulaC26H33NO6
Molecular Weight455.55
Chemical Properties
AppearanceWhite-to-Off-White Crystalline Solid
refractive index1.54
storage tempStore in original container in a cool dark place.
Safety Data

Risk R20/21/22
Safety

Risk Codes: R20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.?
Safety Description: S36/37
S36/37:Wear suitable protective clothing and gloves.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 80200ug/kg (80.2mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 335, 1994.
mouse LD50 oral 3150mg/kg (3150mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 335, 1994.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg) ? Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 335, 1994.
rat LD50 intraperitoneal 43300ug/kg (43.3mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 335, 1994.
rat LD50 oral 880mg/kg (880mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 335, 1994.
rat LD50 subcutaneous 562mg/kg (562mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 335, 1994

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