p-Chlorophenyl isocyanate cas no:104-12-1
Synonyms: Isocyanicacid, p-chlorophenyl ester (6CI,7CI,8CI); 1-Chloro-4-isocyanatobenzene;1-Isocyanato-4-chlorobenzene; 4-Chloro-1-isocyanatobenzene;4-Chloroisocyanatobenzene; 4-Chlorophenyl isocyanate; NSC 76589; p-Chlorophenylisocyanate
Namep-Chlorophenyl isocyanate
CAS104-12-1
SynonymsIsocyanicacid, p-chlorophenyl ester (6CI,7CI,8CI); 1-Chloro-4-isocyanatobenzene;1-Isocyanato-4-chlorobenzene; 4-Chloro-1-isocyanatobenzene;4-Chloroisocyanatobenzene; 4-Chlorophenyl isocyanate; NSC 76589; p-Chlorophenylisocyanate
EINECS(EC#)203-176-9
Molecular FormulaC7H4 Cl N O
Molecular Weight153.57
Appearancecolorless to light yellow liquid
refractive index1.5618
storage temp2-8°C
Sensitive Moisture Sensitive/Lachrymatory
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1
Hazard T+:Verytoxic;
Risk R25;R26;R37/38;R41;R42;R52/53
Safety Hazard Codes:T+,T,C
Risk Statements:25-26-37/38-41-42-52/53
25:Toxic if swallowed
26:Very Toxic by inhalation
37/38:Irritating to eyes, respiratory system and skin
41:Risk of serious damage to eyes
42:May cause sensitization by inhalation
52/53:Harmful to aquatic organisms, may cause long-term adverse
effects in the aquatic environment
Safety Statements:23-26-28-36/37/39-45-61-38-37/39-28A-22
23:Do not breathe gas/fumes/vapor/spray (appropriate wording
to be specified by the manufacturer)
26:In case of contact with eyes, rinse immediately with plenty
of water and seek medical advice
28:After contact with skin, wash immediately with plenty of
... (to be specified by the manufacturer)
36/37/39:Wear suitable protective clothing, gloves and eye/face
protection
45:In case of accident or if you feel unwell, seek medical
advice immediately (show label where possible)
61:Avoid release to the environment. Refer to special instructions
safety data sheet
38:In case of insufficient ventilation, wear suitable respiratory
equipment
37/39:Wear suitable protective clothing, gloves and eye/face
protection
22:Do not breathe dust
RIDADR:UN 2811 6.1/PG 2
WGK Germany:3
HazardClass:6.1
PackingGroup:II
Hazard Note:Toxic/Corrosive/Lachrymatory/Moisture Sensitive
Hazardous Substances Data:104-12-1(Hazardous Substances Data)
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NQ8575000
- CHEMICAL NAME :
- Isocyanic acid, p-chlorophenyl ester
- CAS REGISTRY NUMBER :
- 104-12-1
- LAST UPDATED :
- 199807
- DATA ITEMS CITED :
- 19
- MOLECULAR FORMULA :
- C7-H4-Cl-N-O
- MOLECULAR WEIGHT :
- 153.57
- WISWESSER LINE NOTATION :
- OCNR DG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,931,1986
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0528437
** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 800 ug/m3/1M
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
31(7-9),481,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 138 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Gastrointestinal - gastritis
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0528437
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 113 mg/m3/4H
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - other changes
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555462
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0538092
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 62500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0538092
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 450 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,38,1982
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 53 mg/m3
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - excitement
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 31(9),108,1966
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 6 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0528442
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 53 mg/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 11(4),23,1967
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 9500 mg/kg/2W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes primarily in glomeruli
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0528442
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 ug/m3/24H/80D-C
- TOXIC EFFECTS :
- Liver - other changes
Kidney, Ureter, Bladder - other changes in urine composition
Endocrine - other changes
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 32(10),103,1967
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5 ug/m3/24H/11W-C
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Metabolism (Intermediary) - other proteins
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 32(7),3,1967
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1400 ug/m3/4H/17W-I
- TOXIC EFFECTS :
- Endocrine - changes in spleen weight
Endocrine - changes in thyroid weight
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 31(9),108,1966
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 0.5 mg/m3;Skin JAN 1993
