Bisoprolol fumarate cas no:104344-23-2
Synonyms: (+-)-1-(p-((2-Isopropoxyethoxy)methyl)phenoxy)-3-isopropylamino-2-propanol hemifumarate;Bisoprolol hemifumarate;2-Propanol,1-[4-[[2-(1-methylethoxy)ethoxy]- methyl]phenoxy]-3-[(1-methylethyl)amino]-,(2E)-2-butenedioate (2:1) (salt);but-2-enedioic acid; 1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol;Monocor;Soprol;2-Propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-, (E)-2-butenedioate (2:1) (salt);Concor;Zebeta;Godal;(+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol fumarate (2:1) (salt);Emcor;Maintate;Bisomerck;Bisobloc;Biso-Puren;Fondril;
NameBisoprolol fumarate
CAS104344-23-2
Synonyms(+-)-1-(p-((2-Isopropoxyethoxy)methyl)phenoxy)-3-isopropylamino-2-propanol hemifumarate;Bisoprolol hemifumarate;2-Propanol,1-[4-[[2-(1-methylethoxy)ethoxy]- methyl]phenoxy]-3-[(1-methylethyl)amino]-,(2E)-2-butenedioate (2:1) (salt);but-2-enedioic acid; 1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol;Monocor;Soprol;2-Propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-, (E)-2-butenedioate (2:1) (salt);Concor;Zebeta;Godal;(+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol fumarate (2:1) (salt);Emcor;Maintate;Bisomerck;Bisobloc;Biso-Puren;Fondril;
Molecular FormulaC18H31NO4.C4H4O4
Molecular Weight766.95824
Appearancewhite to offf-white powder
Hazard Xi:Irritant
Risk R22
Safety
Hazard Codes:?
Xn,?
Xi
Risk Statements: 22?
R22:Harmful if swallowed.
WGK Germany: 3
RTECS: UB8390000
Beta-blockers can precipitate asthma and this effect can be dangerous. Beta-blockers should be avoided in patients with a history of asthma or bronchospasm; if there is no alternative, a cardioselective beta-blocker can be used with extreme caution under specialist supervision. atenolol, bisoprolol, METOPROLOL, nebivolol, and (to a lesser extent) ACEBUTOLOL, have less effect on the beta2 (bronchial) receptors and are, therefore, relatively cardioselective, but they are not cardiospecific. They have a lesser effect on airways resistance but are not free of this side-effect.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| dog |
LDLo |
oral |
40mg/kg (40mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2321, 1989. |
| mouse |
LD50 |
intravenous |
111mg/kg (111mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2313, 1989. |
| mouse |
LD50 |
oral |
678mg/kg (678mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2313, 1989. |
| rat |
LD50 |
intravenous |
39mg/kg (39mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2313, 1989. |
| rat |
LD50 |
oral |
940mg/kg (940mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2313, 1989. |
