1-Azabicyclo[2.2.2]octane-3-methanol,a,a-diphenyl-, hydrochloride (1:1) cas no:10447-38-8

Name1-Azabicyclo[2.2.2]octane-3-methanol,a,a-diphenyl-, hydrochloride (1:1)
CAS10447-38-8
Synonyms1-Azabicyclo[2.2.2]octane-3-methanol,a,a-diphenyl-, hydrochloride (9CI); 3-Quinuclidinemethanol,a,a-diphenyl-, hydrochloride (7CI,8CI); Phencarol;Quifenadine hydrochloride
Molecular FormulaC20H23 N O . Cl H
Molecular Weight329.90

Safety Poison by ingestion and intravenous routes. When heated to decomposition it emits very toxic fumes of NOx and HCl.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

VD4830000

CHEMICAL NAME :

3-Quinuclidinemethanol, alpha,alpha-diphenyl-, hydrochloride

CAS REGISTRY NUMBER :

10447-38-8

LAST UPDATED :

199603

DATA ITEMS CITED :

4

MOLECULAR FORMULA :

C20-H23-N-O.Cl-H

MOLECULAR WEIGHT :

329.90

WISWESSER LINE NOTATION :

T66 A B CNTJ AXQR&R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

440 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 40,42,1977

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

370 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 40,42,1977

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

62 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity)

REFERENCE :

RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 40,42,1977

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

860 mg/kg

TOXIC EFFECTS :

Vascular - BP elevation not characterized in autonomic section Lungs, Thorax, or Respiration - bronchiolar dilation Immunological Including Allergic - increased immune response

REFERENCE :

FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,148,1980