Ethanamine,2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl- cas no:10540-29-1
Synonyms: Ethanamine,2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-, (Z)-;Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-butenyl]phenoxy]-N,N-dimethyl-(9CI);Ethylamine, 2-[p-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-, (Z)-(8CI);(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine;ICI47699;Mammaton;Novaldex;Z-Tamoxifen;trans-Tamoxifen;? Tamoxifen;
NameEthanamine,2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-
CAS10540-29-1
SynonymsEthanamine,2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-, (Z)-;Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-butenyl]phenoxy]-N,N-dimethyl-(9CI);Ethylamine, 2-[p-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-, (Z)-(8CI);(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine;ICI47699;Mammaton;Novaldex;Z-Tamoxifen;trans-Tamoxifen;? Tamoxifen;
EINECS(EC#)234-118-0
Molecular FormulaC26H29NO
Molecular Weight371.51456
Appearancefine off-white crystalline powder
refractive index1.582
storage temp2-8°C
Hazard T:Toxic
Risk R45;R60;R61;R64
Safety
Confirmed human carcinogen. Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by an unspecified route: nausea or vomiting, leukopenia, thrombocytopenia, and skin changes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes:
T
Xi
Risk Statements:
R45:May cause cancer.?
R60:May impair fertility.?
R61:May cause harm to the unborn child.?
R64:May cause harm to breastfed babies.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements:
S53:Avoid exposure - obtain special instructions before use.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36:Wear suitable protective clothing.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: KR5919600
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD50 |
intraperitoneal |
575mg/kg (575mg/kg) |
? |
Journal of Antibiotics. Vol. 43, Pg. 1533, 1990. |
| mouse |
LD50 |
oral |
2150mg/kg (2150mg/kg) |
? |
Drugs of the Future. Vol. 9, Pg. 186, 1984. |
| rat |
LD50 |
intraperitoneal |
700mg/kg (700mg/kg) |
? |
Drugs of the Future. Vol. 9, Pg. 186, 1984. |
| rat |
LD50 |
oral |
4100mg/kg (4100mg/kg) |
? |
Drugs of the Future. Vol. 9, Pg. 186, 1984. |
| women |
TDLo |
oral |
5600ug/kg/1W- (5.6mg/kg) |
skin and appendages (skin): breast: other |
British Medical Journal. Vol. 291, Pg. 1172, 1985. |
| women |
TDLo |
unreported |
200ug/kg/D (0.2mg/kg) |
gastrointestinal: nausea or vomiting blood: leukopenia blood: thrombocytopenia |
Cancer Treatment Reports. Vol. 60, Pg. 1431, 1976. |
| women |
TDLo |
unreported |
5600ug/kg/2W- (5.6mg/kg) |
blood: normocytic anemia musculoskeletal: joints
|
British Journal of Rheumatology. Vol. 33, Pg. 583, 1994. |
