105628-07-7|Fasudil hydrochlorideProducts Supply - Chemical intermediates Network

Fasudil hydrochloride cas no:105628-07-7

Synonyms: Isoquinoline,5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:1);1H-1,4-Diazepine,hexahydro-1-(5-isoquinolinylsulfonyl)-, monohydrochloride (9CI);1-(5-Isoquinolinesulfonyl)homopiperazine hydrochloride;Fasudilhydrochloride;

Identification

NameFasudil hydrochloride
CAS105628-07-7
SynonymsIsoquinoline,5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:1);1H-1,4-Diazepine,hexahydro-1-(5-isoquinolinylsulfonyl)-, monohydrochloride (9CI);1-(5-Isoquinolinesulfonyl)homopiperazine hydrochloride;Fasudilhydrochloride;
Molecular FormulaC₁₄H₁₈ClN₃O₂S
Molecular Weight327.82962

Chemical Properties

AppearanceWhite Solid

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
monkey	LD50	intravenous	20mg/kg (20mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995.
mouse	LD50	intravenous	67600ug/kg (67.6mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: STRAUB TAIL	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
mouse	LD50	oral	274mg/kg (274mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
mouse	LD50	subcutaneous	124mg/kg (124mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
rat	LD50	intravenous	59900ug/kg (59.9mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
rat	LD50	oral	335mg/kg (335mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
rat	LD50	subcutaneous	123mg/kg (123mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,

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Fasudil hydrochloride cas no:105628-07-7

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