105628-07-7|Fasudil hydrochlorideProducts Supply - Chemical intermediates Network

Fasudil hydrochloride cas no:105628-07-7

Synonyms: Isoquinoline,5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:1);1H-1,4-Diazepine,hexahydro-1-(5-isoquinolinylsulfonyl)-, monohydrochloride (9CI);1-(5-Isoquinolinesulfonyl)homopiperazine hydrochloride;Fasudilhydrochloride;

Identification

NameFasudil hydrochloride
CAS105628-07-7
SynonymsIsoquinoline,5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:1);1H-1,4-Diazepine,hexahydro-1-(5-isoquinolinylsulfonyl)-, monohydrochloride (9CI);1-(5-Isoquinolinesulfonyl)homopiperazine hydrochloride;Fasudilhydrochloride;
Molecular FormulaC₁₄H₁₈ClN₃O₂S
Molecular Weight327.82962

Chemical Properties

AppearanceWhite Solid

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
monkey	LD50	intravenous	20mg/kg (20mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995.
mouse	LD50	intravenous	67600ug/kg (67.6mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: STRAUB TAIL	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
mouse	LD50	oral	274mg/kg (274mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
mouse	LD50	subcutaneous	124mg/kg (124mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
rat	LD50	intravenous	59900ug/kg (59.9mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
rat	LD50	oral	335mg/kg (335mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
rat	LD50	subcutaneous	123mg/kg (123mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,

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Shandong Novatech Pharmaceutical Co., Ltd.: Tel:+86-531-55582725; Address: R801,Lianggu Building, No.6 Qilihe Road,

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ZHEJIANG XINHUA PHARMACEUTICAL CO., LTD.: Tel:+86-576-85588383; Address: Linhai Zone, Linhai, Zhejiang, China

Suzhou Leader Chemical Co., Ltd.: Tel:0086-512-68412652 68412692; Address: 6# Jinshan Road, New District, Suzhou

Hangzhou Chempro Tech Co., Ltd.: Tel:086-0571-87759730; Address: Wen San road 90# Hang Zhou Zhe Jiang P.R.

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Inter-Chemical Ltd.: Tel:+86-(755)-82187211, 82192202; Address: B-1108/1109, Tian An International Bldg., RenMin Nan Road, ShenZhen 518005,

Chengdu Sino-Strong Pharmaceutical Co., Ltd.: Tel:+86-(28)-82783659; Address: 459 West Haike Road, Cross-Straits Technological Industry Park, Wenjiang District, Chengdu 611130,

Yong Yang Pharmaceutical Co., Ltd.: Tel:+86-(531)-82373730; Address: C419, No.19 Huaneng Road, Jinan, Shandong 250100,

Shanghai Twisun Bio-pharm Co.,Ltd.: Tel:+86-(21)-37285116; Address: 221,Building F,No.688 Qiushi Road, Jinshan District, Shanghai 201512,

Shanghai DND Pharm-Technology Co.,Inc.: Tel:+86-(21)-58783620, 58783570; Address: No.2-18A, Lane 85, Rongcheng Road, Pudong, Shanghai 200120,

Huei-Ho International Co., Ltd.: Tel:+86-(21)-6273-7219, 6273-6279; Address: 20B,No.2,Lane 600,Peakway Tower,Tianshan Road, Shanghai, shanghai 200051,

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ALL PRO CORPORATION: Tel:86-532-82850205; Address: No.592, TONGHE ROAD, QINGDAO, CHINA

Fasudil hydrochloride cas no:105628-07-7

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