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P-Chlorophenol cas no:106-48-9

Synonyms: 4-Chlorophenol solution; Parachlorophenol; Para chlorophenol; 4-chloro phenol; 4-chloro-1-hydroxybenzene; 4-chloro-pheno; 4-Chlorophenol(form2); 4-chloro-phenole; Applied 3-78; applied3-78; chlorophenols,solid; p-Chlorfenol; P-CHLORO PHENOL; 4-Hydroxychlorobenzene

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Identification
NameP-Chlorophenol
CAS106-48-9
Synonyms4-Chlorophenol solution; Parachlorophenol; Para chlorophenol; 4-chloro phenol; 4-chloro-1-hydroxybenzene; 4-chloro-pheno; 4-Chlorophenol(form2); 4-chloro-phenole; Applied 3-78; applied3-78; chlorophenols,solid; p-Chlorfenol; P-CHLORO PHENOL; 4-Hydroxychlorobenzene
EINECS(EC#)203-402-6
Molecular FormulaC6H5ClO
Molecular Weight128.56
Chemical Properties
Appearanceoff-white to light tan crystals or powder
refractive index1.5579
storage temp0-6°C
Sensitive Air Sensitive
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1
Safety Data

Hazard Xn:Harmful
Risk R20/21/22;R51/53
Safety

Poison by inhalation and intraperitoneal routes. Moderately toxic by ingestion, skin contact, and subcutaneous routes. A severe skin and eye irritant. Human systemic effects by inhalation: excitement, irritability. Mutation data reported. Combustible when exposed to heat or flame. To fight fire, use water, spray, mist, fog, foam, dry chemical. When heated to decomposition it emits toxic fumes of Cl?.
Hazard Codes:?HarmfulXn,DangerousN
Risk Statements: 20/21/22-51/53-50?
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.?
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.?
R50:Very toxic to aquatic organisms.
Safety Statements: 28-61-28A-24/25-60?
S28:After contact with skin, wash immediately with plenty of soap-suds.?
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.?
S24/25:Avoid contact with skin and eyes.?
S60:This material and its container must be disposed of as hazardous waste.
RIDADR: UN 2020 6.1/PG 3
WGK Germany: 2
RTECS: SK2800000
HazardClass: 6.1
PackingGroup of 4-Chlorophenol (CAS NO.106-48-9): III


HS Code 29081000

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TCLo inhalation 10gm/m3/8H (10000mg/m3) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: IRRITABILITY		 Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 29(10), Pg. 37, 1964.
mammal (species unspecified) LD50 oral 500mg/kg (500mg/kg) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980.
mammal (species unspecified) LD50 skin 1gm/kg (1000mg/kg) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980.
mouse LCLo inhalation 3200mg/m3/2H (3200mg/m3) BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LIVER: OTHER CHANGES		 Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(7-8), Pg. 9, 1992.
mouse LD50 intraperitoneal 332mg/kg (332mg/kg) ? Journal of Medicinal Chemistry. Vol. 18, Pg. 868, 1975.
mouse LD50 oral 367mg/kg (367mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: COMA		 Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny. Journal of Experimental and Clinical Medicine. Vol. 25, Pg. 339, 1985.
mouse LD50 unreported 605mg/kg (605mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 54(1), Pg. 68, 1989.
rat LC50 inhalation 11mg/m3 (11mg/m3) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 29(10), Pg. 37, 1964.
rat LD50 intraperitoneal 281mg/kg (281mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 British Journal of Pharmacology and Chemotherapy. Vol. 13, Pg. 20, 1958.
rat LD50 oral 670mg/kg (670mg/kg) ? Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 2, Pg. 76, 1943.
rat LD50 skin 1500mg/kg (1500mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE		 Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 29(10), Pg. 37, 1964.
rat LD50 subcutaneous 1030mg/kg (1030mg/kg) ? Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 2, Pg. 76, 1943.
rat LD50 unreported 625mg/kg (625mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT		 Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 54(1), Pg. 68, 1989.

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