106266-06-2|RisperidalProducts Supply - Chemical intermediates Network

Risperidal cas no:106266-06-2

Synonyms: Risperdal (TN);Risperidone;3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino)ethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido(1,2-a)pyrimidin-4-one;Apexidone;BRN 4891881;HSDB 7580;Psychodal;R 64 766;Risperdal Consta;Risperidona;Rispolept;

Identification

NameRisperidal
CAS106266-06-2
SynonymsRisperdal (TN);Risperidone;3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino)ethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido(1,2-a)pyrimidin-4-one;Apexidone;BRN 4891881;HSDB 7580;Psychodal;R 64 766;Risperdal Consta;Risperidona;Rispolept;
Molecular FormulaC₂₃H₂₇FN₄O₂
Molecular Weight410.49 .

Chemical Properties

Appearancecrystalline solid
refractive index1.676
storage tempRoom temp

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(a)

Safety Data

Hazard T: Toxic;
Risk R25
Safety

Hazard Codes:? Toxic T
Risk Statements: 25?
R25 :Toxic if swallowed.
Safety Statements: 28-36-45?
S28:After contact with skin, wash immediately with plenty of soap-suds.?
S36:Wear suitable protective clothing.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: 3249
RTECS: UV1164800
HazardClass: 6.1(a)
PackingGroup: II

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	268ug/kg (0.268mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: TREMOR BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Annals of Pharmacotherpy. Vol. 30, Pg. 360, 1996. ?
dog	LD50	intravenous	14100ug/kg (14.1mg/kg)	?	Journal of Pharmacology and Experimental Therapeutics. Vol. 244, Pg. 685, 1988. ?
dog	LD50	oral	18300ug/kg (18.3mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 2991, 1993.
man	TDLo	oral	114ug/kg/2D-I (0.114mg/kg)	BEHAVIORAL: WAKEFULNESS BEHAVIORAL: EUPHORIA BEHAVIORAL: EXCITEMENT	American Journal of Psychiatry. Vol. 153, Pg. 1234, 1996.
man	TDLo	oral	429ug/kg (0.429mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE	American Journal of Emergency Medicine. Vol. 16, Pg. 498, 1998. ?
man	TDLo	oral	429ug/kg/15D- (0.429mg/kg)	BRAIN AND COVERINGS: CHANGES IN SURFACE EEG BEHAVIORAL: ALTERATION OF OPERANT CONDITIONING BEHAVIORAL: ANOREXIA (HUMAN	Journal of Clinical Psychiatry. Vol. 58, Pg. 323, 1997.
man	TDLo	oral	3428ug/kg (3.428mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE	Annals of Emergency Medicine. Vol. 22, Pg. 1908, 1993. ?
man	TDLo	oral	3857ug/kg (3.857mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: PULSE RATE	Journal of Toxicology, Clinical Toxicology. Vol. 37, Pg. 893, 1999. ?
mouse	LD50	intravenous	26900ug/kg (26.9mg/kg)	?	Journal of Pharmacology and Experimental Therapeutics. Vol. 244, Pg. 685, 1988. ?
mouse	LD50	oral	63100ug/kg (63.1mg/kg)	?	Journal of Pharmacology and Experimental Therapeutics. Vol. 244, Pg. 685, 1988. ?
rat	LD50	intravenous	34300ug/kg (34.3mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 2991, 1993.
rat	LD50	oral	56600ug/kg (56.6mg/kg)	?	Journal of Pharmacology and Experimental Therapeutics. Vol. 244, Pg. 685, 1988. ?
rat	LD50	subcutaneous	98mg/kg (98mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 2991, 1993.
women	TDLo	oral	400ug/kg (0.4mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	American Journal of Emergency Medicine. Vol. 16, Pg. 498, 1998. ?
women	TDLo	oral	880ug/kg (0.88mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	American Journal of Emergency Medicine. Vol. 16, Pg. 498, 1998. ?
women	TDLo	oral	1840ug/kg (1.84mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: HEADACHE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Journal of Clinical Psychiatry. Vol. 56, Pg. 514, 1995. ?
women	TDLo	oral	2mg/kg (2mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	Journal of Clinical Pyschopharmacology. Vol. 17, Pg. 325, 1997.
women	TDLo	oral	2200ug/kg (2.2mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	Therapie. Vol. 52, Pg. 155, 1997. ?
women	TDLo	oral	648mg/kg/77W- (648mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Journal of Clinical Psychiatry. Vol. 59, Pg. 478, 1998.

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