| child |
TDLo |
oral |
268ug/kg (0.268mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: TREMOR
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) |
Annals of Pharmacotherpy. Vol. 30, Pg. 360, 1996.
? |
| dog |
LD50 |
intravenous |
14100ug/kg (14.1mg/kg) |
? |
Journal of Pharmacology and Experimental Therapeutics. Vol. 244, Pg. 685, 1988.
? |
| dog |
LD50 |
oral |
18300ug/kg (18.3mg/kg) |
BEHAVIORAL: MUSCLE WEAKNESS
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 2991, 1993. |
| man |
TDLo |
oral |
114ug/kg/2D-I (0.114mg/kg) |
BEHAVIORAL: WAKEFULNESS
BEHAVIORAL: EUPHORIA
BEHAVIORAL: EXCITEMENT |
American Journal of Psychiatry. Vol. 153, Pg. 1234, 1996. |
| man |
TDLo |
oral |
429ug/kg (0.429mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE
CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE |
American Journal of Emergency Medicine. Vol. 16, Pg. 498, 1998.
? |
| man |
TDLo |
oral |
429ug/kg/15D- (0.429mg/kg) |
BRAIN AND COVERINGS: CHANGES IN SURFACE EEG
BEHAVIORAL: ALTERATION OF OPERANT CONDITIONING
BEHAVIORAL: ANOREXIA (HUMAN |
Journal of Clinical Psychiatry. Vol. 58, Pg. 323, 1997. |
| man |
TDLo |
oral |
3428ug/kg (3.428mg/kg) |
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE |
Annals of Emergency Medicine. Vol. 22, Pg. 1908, 1993.
? |
| man |
TDLo |
oral |
3857ug/kg (3.857mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE
CARDIAC: PULSE RATE |
Journal of Toxicology, Clinical Toxicology. Vol. 37, Pg. 893, 1999.
? |
| mouse |
LD50 |
intravenous |
26900ug/kg (26.9mg/kg) |
? |
Journal of Pharmacology and Experimental Therapeutics. Vol. 244, Pg. 685, 1988.
? |
| mouse |
LD50 |
oral |
63100ug/kg (63.1mg/kg) |
? |
Journal of Pharmacology and Experimental Therapeutics. Vol. 244, Pg. 685, 1988.
? |
| rat |
LD50 |
intravenous |
34300ug/kg (34.3mg/kg) |
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 2991, 1993. |
| rat |
LD50 |
oral |
56600ug/kg (56.6mg/kg) |
? |
Journal of Pharmacology and Experimental Therapeutics. Vol. 244, Pg. 685, 1988.
? |
| rat |
LD50 |
subcutaneous |
98mg/kg (98mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 2991, 1993. |
| women |
TDLo |
oral |
400ug/kg (0.4mg/kg) |
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP |
American Journal of Emergency Medicine. Vol. 16, Pg. 498, 1998.
? |
| women |
TDLo |
oral |
880ug/kg (0.88mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) |
American Journal of Emergency Medicine. Vol. 16, Pg. 498, 1998.
? |
| women |
TDLo |
oral |
1840ug/kg (1.84mg/kg) |
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
BEHAVIORAL: HEADACHE
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION |
Journal of Clinical Psychiatry. Vol. 56, Pg. 514, 1995.
? |
| women |
TDLo |
oral |
2mg/kg (2mg/kg) |
CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION |
Journal of Clinical Pyschopharmacology. Vol. 17, Pg. 325, 1997. |
| women |
TDLo |
oral |
2200ug/kg (2.2mg/kg) |
CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION |
Therapie. Vol. 52, Pg. 155, 1997.
? |
| women |
TDLo |
oral |
648mg/kg/77W- (648mg/kg) |
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
BEHAVIORAL: ATAXIA
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) |
Journal of Clinical Psychiatry. Vol. 59, Pg. 478, 1998. |
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