Granisetron hydrochloride cas no:107007-99-8
Synonyms: 1H-Indazole-3-carboxamide,1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-, monohydrochloride(9CI);BRL 43694A;Kytril;1H-Indazole-3-carboxamide,1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-, hydrochloride(1:1);1H-Indazole-3-carboxamide,1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-, monohydrochloride, endo-;
NameGranisetron hydrochloride
CAS107007-99-8
Synonyms1H-Indazole-3-carboxamide,1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-, monohydrochloride(9CI);BRL 43694A;Kytril;1H-Indazole-3-carboxamide,1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-, hydrochloride(1:1);1H-Indazole-3-carboxamide,1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-, monohydrochloride, endo-;
Molecular FormulaC18H25ClN4O
Molecular Weight348.87
AppearanceWhite to Off-White Crystalline Solid
refractive index1.69
storage tempRoom temp
Hazard Xn: Harmful;Xi: Irritant;
Risk R22
Safety
Hazard Codes:?
Xn,
Xi
Risk Statements: 22-62-37/38-36/37/38-36?
R22:Harmful if swallowed.?
R62:Risk of impaired fertility.?
R37/38:Irritating to respiratory system and skin.?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R36:Irritating to eyes.
Safety Statements: 26-36-37?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.?
S37:Wear suitable gloves.
RTECS: NK7882200
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| dog |
LDLo |
intravenous |
3mg/kg (3mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: TREMOR
GASTROINTESTINAL: NAUSEA OR VOMITING |
Yakkyoku. Pharmacy. Vol. 43, Pg. 589, 1992. |
| dog |
LDLo |
oral |
15mg/kg (15mg/kg) |
BEHAVIORAL: TREMOR
GASTROINTESTINAL: NAUSEA OR VOMITING |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 2697, 1995. |
| mouse |
LD50 |
intravenous |
17mg/kg (17mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 4991, 1990. |
| mouse |
LD50 |
oral |
350mg/kg (350mg/kg) |
? |
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995. |
| rat |
LD50 |
intravenous |
14mg/kg (14mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ATAXIA
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) |
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 4991, 1990. |
| rat |
LD50 |
oral |
350mg/kg (350mg/kg) |
? |
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995. |
