Thiazolidine,3-[bis(1-aziridinyl)phosphinyl]-2-methyl- cas no:1078-79-1

Synonyms: Phosphineoxide, bis(1-aziridinyl)(2-methyl-3-thiazolidinyl)- (7CI,8CI); IE-35; Imifos;Imiphos; Marcophan; Marcophane; Markofane

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Identification
Chemical Properties
Safety Data
Toxicity

Identification

NameThiazolidine,3-[bis(1-aziridinyl)phosphinyl]-2-methyl-
CAS1078-79-1
SynonymsPhosphineoxide, bis(1-aziridinyl)(2-methyl-3-thiazolidinyl)- (7CI,8CI); IE-35; Imifos;Imiphos; Marcophan; Marcophane; Markofane
Molecular FormulaC8H16 N3 O P S
Molecular Weight233.30

Chemical Properties

refractive index1.637

Safety Data

Safety

Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of SO_x, PO_x, and NO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	142mg/kg (142mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	"Imifos," Giller, S.A., ed., Izd, Riga, USSR, 1968Vol. -, Pg. 129, 1968.
mouse	LD50	oral	225mg/kg (225mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	"Imifos," Giller, S.A., ed., Izd, Riga, USSR, 1968Vol. -, Pg. 129, 1968.
rat	LD50	intraperitoneal	18700ug/kg (18.7mg/kg)	BLOOD: LEUKOPENIA	Farmakologiya i Toksikologiya Vol. 37, Pg. 464, 1974.

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