Tetrahydrofuran cas no:109-99-9

NameTetrahydrofuran
CAS109-99-9
SynonymsTHF; tetrahydrofuran B&J brand 4 L; 99%; oxolane; Sodium tri-sec-butylborohydride; Tetrahydrofuran(Stabilized); TetrahydrofuranForHplc; TetrahydrofuranGr; TetrahydrofuranForSynthesis;
EINECS(EC#)203-726-8
Molecular FormulaC4H8O
Molecular Weight72.11

AppearanceClear liquid
refractive index1.407
storage temp2-8°C
Sensitive Air Sensitive & Hygroscopic

Hazardclass3

Hazard F:Flammable
Risk R11;R19;R36/37
Safety

Hazard Codes?of Tetrahydrofuran (CAS NO.109-99-9):?Xi,F
Risk Statements: 36/37/38-19-11?
R36/37/38: Irritating to eyes, respiratory system and skin.?
R19: May form explosive peroxides.?
R11: Highly flammable.
Safety Statements: 26-36-33-29-16?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36: Wear suitable protective clothing.?
S33: Take precautionary measures against static discharges.?
S29: Do not empty into drains.?
S16: Keep away from sources of ignition.
RIDADR: UN 2924 3/PG 2
WGK Germany: 1
RTECS: MD0916000
F: 3-10-23
HazardClass: 3
PackingGroup: II
HS Code: 29321100
Hazardous Substances Data 109-99-9(Hazardous Substances Data)
Moderately toxic by ingestion and intraperitoneal routes. Mildly toxic by inhalation. Human systemic effects by inhalation: general anesthesia. Mutation data reported. Irritant to eyes and mucous membranes. Narcotic in high concentrations. Reported as causing injury to liver and kidneys.
?Flammable liquid. A very dangerous fire hazard when exposed to heat, flames, oxidizers. Explosive in the form of vapor when exposed to heat or flame. In common with ethers, unstabilized tetrahydrofuran forms thermally explosive peroxides on exposure to air. Stored THF must always be tested for peroxide prior to distillation. Peroxides can be removed by treatment with strong ferrous sulfate solution made slightly acidic with sodium bisulfate. Caustic alkalies deplete the inhibitor in THF and may subsequently cause an explosive reaction. Explosive reaction with KOH, NaAlH₂, NaOH, sodium tetrahydroaluminate. Reacts with 2-aminophenol + potassium dioxide to form an explosive product. Reacts with lithium tetrahydroaluminate or borane to form explosive hydrogen gas. Violent reaction with metal halides (e.g., hafnium tetrachloride, titanium tetrachloride, zirconium tetrachloride). Vigorous reaction with bromine, calcium hydride + heat. Can react with oxidizing materials. To fight fire, use foam, dry chemical, CO₂. When heated to decomposition it emits acrid smoke and irritating fumes. See also 2-TETRAHYDROFURYL HYDROPEROXIDE. ? ?

?

HS Code 29321100

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	oral	2300mg/kg (2300mg/kg)	?	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 34(9), Pg. 114, 1969.
guinea pig	LDLo	intraperitoneal	500mg/kg (500mg/kg)	LIVER: FATTY LIVER DEGERATION	American Industrial Hygiene Association Journal. Vol. 35, Pg. 21, 1974.
human	TCLo	inhalation	25000ppm (25000ppm)	BEHAVIORAL: GENERAL ANESTHETIC	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 580, 1969.
mouse	LCLo	inhalation	24000mg/m3/2H (24000mg/m3)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 5, Pg. 21, 1963.
mouse	LD50	intraperitoneal	1900mg/kg (1900mg/kg)	?	Sangyo Igaku. Japanese Journal of Industrial Health. Vol. 24, Pg. 373, 1982.
rabbit	LC	inhalation	> 1200ppm/4H (1200ppm)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION	Sumitomo Sangyo Eisei. Sumitomo Industrial Health. Vol. 18, Pg. 89, 1982.
rat	LC50	inhalation	21000ppm/3H (21000ppm)	BEHAVIORAL: SLEEP LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: NAUSEA OR VOMITING	Sumitomo Sangyo Eisei. Sumitomo Industrial Health. Vol. 20, Pg. 141, 1984.
rat	LD50	intraperitoneal	2900mg/kg (2900mg/kg)	?	Sangyo Igaku. Japanese Journal of Industrial Health. Vol. 24, Pg. 373, 1982.
rat	LD50	oral	1650mg/kg (1650mg/kg)	?	GAF Material Safety Data Sheet.