dog |
LD50 |
intravaginal |
> 500mg/kg (500mg/kg) |
|
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 40, Pg. 444, 1998. |
mouse |
LD50 |
intraperitoneal |
460mg/kg (460mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: ATAXIA |
Kiso to Rinsho. Clinical Report. Vol. 10, Pg. 1852, 1976. |
mouse |
LD50 |
intravaginal |
> 500mg/kg (500mg/kg) |
|
Oyo Yakuri. Pharmacometrics. Vol. 48, Pg. 189, 1994. |
mouse |
LD50 |
intravenous |
274mg/kg (274mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: ATAXIA |
Kiso to Rinsho. Clinical Report. Vol. 10, Pg. 1852, 1976. |
mouse |
LD50 |
oral |
> 10gm/kg (10000mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 687, 1982. |
mouse |
LD50 |
subcutaneous |
899mg/kg (899mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ATAXIA |
Kiso to Rinsho. Clinical Report. Vol. 10, Pg. 1852, 1976. |
rat |
LD50 |
intraperitoneal |
523mg/kg (523mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: ATAXIA |
Kiso to Rinsho. Clinical Report. Vol. 10, Pg. 1852, 1976. |
rat |
LD50 |
intravaginal |
> 500mg/kg (500mg/kg) |
|
Oyo Yakuri. Pharmacometrics. Vol. 48, Pg. 189, 1994. |
rat |
LD50 |
intravenous |
468mg/kg (468mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Kiso to Rinsho. Clinical Report. Vol. 10, Pg. 1852, 1976. |
rat |
LD50 |
oral |
> 10gm/kg (10000mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 687, 1982. |
rat |
LD50 |
subcutaneous |
1005mg/kg (1005mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ATAXIA |
Kiso to Rinsho. Clinical Report. Vol. 10, Pg. 1852, 1976. |
women |
TDLo |
intravenous |
4mg/kg (4mg/kg) |
GASTROINTESTINAL: NAUSEA OR VOMITING
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Japan Medical Gazette. Vol. 18(5), Pg. 10, 1981. |