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2-Butyne-1,4-diol cas no:110-65-6

Synonyms: 1,4-Dihydroxy-2-butyne; Butynediol,99%; 1,4-Butynediol; but-2-yne-1,4-diol; butynediol; 1,4-butyne diol; BOZ; butyne-1.4-diol; 1,4-butinodiol; 1,4-Dimethoxyacetylene; 2-Butin-1,4-diol; 2-butin-1,4-diol(czechoslovakia); 2-Butine-1,4-diol; 2-Butynediol; agrisynthb3d; Bis(hydroxymethyl)acetylene; butynediol-1,4(french); Dihydroxydimethylacetylene; 1,4-BUTENEDIOL; 1,2-DIHYDROXYDIMETHYLACETYLENE

Identification
Name2-Butyne-1,4-diol
CAS110-65-6
Synonyms1,4-Dihydroxy-2-butyne; Butynediol,99%; 1,4-Butynediol; but-2-yne-1,4-diol; butynediol; 1,4-butyne diol; BOZ; butyne-1.4-diol; 1,4-butinodiol; 1,4-Dimethoxyacetylene; 2-Butin-1,4-diol; 2-butin-1,4-diol(czechoslovakia); 2-Butine-1,4-diol; 2-Butynediol; agrisynthb3d; Bis(hydroxymethyl)acetylene; butynediol-1,4(french); Dihydroxydimethylacetylene; 1,4-BUTENEDIOL; 1,2-DIHYDROXYDIMETHYLACETYLENE
EINECS(EC#)203-788-6
Molecular FormulaC4H6O2
Molecular Weight86.09
Chemical Properties
Appearancewhite to light-brown solid or brownish-yellow aqueous solution
refractive index1.4804
storage tempRefrigerator
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1
Safety Data

Hazard T:Toxic
Risk R21;R23/25;R34;R43;R48/22
Safety

A poison by ingestion. A skin sensitizer upon long or repeated contact. Moderately explosive. When heated to decomposition it emits acrid smoke and fumes and may explode. Explosive reaction with traces of alkalies, alkali earth hydroxides, halide salts, strong acids, mercury salts + strong acids. See also ACETYLENE COMPOUNDS and ALKYNES.
Heating with strongly alkaline materials should be avoided.
Butynediol(110-65-6) is corrosive and irritates the skin and eyes.?
Hazard Codes:?ToxicT,CorrosiveC
Risk Statements: 21-23/25-34-43-48/22?
R21:Harmful in contact with skin.?
R23/25:Toxic by inhalation and if swallowed.?
R34:Causes burns.?
R43:May cause sensitization by skin contact.?
R48/22:Harmful: danger of serious damage to health by prolonged exposure if swallowed.
Safety Statements: 25-26-36/37/39-45-46?
S25:Avoid contact with eyes.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S46:If swallowed, seek medical advice immediately and show this container or label.
RIDADR: UN 2716 6.1/PG 3
WGK Germany: 2
RTECS: ES0525000
F: 23-10
HazardClass: 6.1
PackingGroup: III
HS Code: 29053980


HS Code 29053980

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 75mg/kg (75mg/kg) ? Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
guinea pig LD50 oral 130mg/kg (130mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BLOOD: OTHER CHANGES
Hygiene and Sanitation Vol. 33(1-3), Pg. 41, 1968.
mouse LCLo inhalation 150mg/m3/2H (150mg/m3) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI

BLOOD: HEMORRHAGE
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 13, 1965.
mouse LD50 oral 105mg/kg (105mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BLOOD: OTHER CHANGES
Hygiene and Sanitation Vol. 33(1-3), Pg. 41, 1968.
rabbit LD50 oral 150mg/kg (150mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BLOOD: OTHER CHANGES
Hygiene and Sanitation Vol. 33(1-3), Pg. 41, 1968.
rat LCLo inhalation 150mg/m3/2H (150mg/m3) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI

BLOOD: HEMORRHAGE
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 13, 1965.
rat LD50 intraperitoneal 52435ug/kg (52.435mg/kg) ? Journal of Pharmacy and Pharmacology. Vol. 26, Pg. 597, 1974.
rat LD50 oral 105mg/kg (105mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BLOOD: OTHER CHANGES
Hygiene and Sanitation Vol. 33(1-3), Pg. 41, 1968.

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