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Morpholine cas no:110-91-8

Synonyms: 1-Oxa-4-azacyclohexane; Tetrahydro-2H-1,4-oxazine; morpholine sigmaultra; Morpholine-2,2,3,3,5,5,6,6-d8; tetrahydro-1,4-oxazine; Morpholine 99+ %

Identification
NameMorpholine
CAS110-91-8
Synonyms1-Oxa-4-azacyclohexane; Tetrahydro-2H-1,4-oxazine; morpholine sigmaultra; Morpholine-2,2,3,3,5,5,6,6-d8; tetrahydro-1,4-oxazine; Morpholine 99+ %
EINECS(EC#)203-815-1
Molecular FormulaC4H9NO
Molecular Weight87.12
Chemical Properties
Appearanceaqueous solution with a fishlike odor
refractive index1.453-1.455
storage tempStore at R.T.
Sensitive Hygroscopic
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass8
Safety Data

Hazard C:Corrosive
Risk R10;R20/21/22;R34
Safety

Moderately toxic by ingestion, inhalation, skin contact, and intraperitoneal routes. Mutation data reported. A corrosive irritant to skin, eyes, and mucous membranes. Can cause kidney damage. Questionable carcinogen with experimental neoplastigenic data. Flammable liquid. A very dangerous fire hazard when exposed to flame, heat, or oxidizers; can react with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. Mixtures with nitromethane are explosive. May ignite spontaneously in contact with cellulose nitrate of high surface area. When heated to decomposition it emits highly toxic fumes of NOx.?
Hazard Codes:?CorrosiveC
Risk Statements: 10-20/21/22-34?
R10:Flammable.?
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.?
R34:Causes burns.
Safety Statements: 23-36-45?
S23:Do not breathe vapour.?
S36:Wear suitable protective clothing.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2054 8/PG 1
WGK Germany: 3
RTECS: QD6475000
HazardClass: 8
PackingGroup: I


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo oral 100mg/kg (100mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 236, 1939.
mammal (species unspecified) LC50 inhalation 12000mg/m3 (12000mg/m3) ? Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 90, 1975.
mammal (species unspecified) LD50 oral 1220mg/kg (1220mg/kg) ? Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 90, 1975.
mouse LC50 inhalation 1320mg/m3/2H (1320mg/m3) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 8, Pg. 60, 1966.
mouse LD50 intraperitoneal 413mg/kg (413mg/kg) ? Cancer Vol. 2, Pg. 1055, 1949.
mouse LD50 oral 525mg/kg (525mg/kg) BEHAVIORAL: SLEEP

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Biomedica Biochimica Acta. Vol. 44, Pg. 795, 1985.
mouse LD50 subcutaneous 458mg/kg (458mg/kg) ? United States Patent Document. Vol. #4576951,
rabbit LD50 skin 500uL/kg (0.5mL/kg) ? AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 10, Pg. 61, 1954.
rat LC50 inhalation 8000ppm/8H (8000ppm) ? Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 85, 1974.
rat LD50 oral 1450mg/kg (1450mg/kg) ? Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 10, Pg. 25, 1968.
rat LDLo unreported 1600mg/kg (1600mg/kg) ? "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 662, 1969.

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