1H-Indene-5-sulfonamide,N-[[(4-chlorophenyl)amino]carbonyl]-2,3-dihydro- cas no:110311-27-8

Name1H-Indene-5-sulfonamide,N-[[(4-chlorophenyl)amino]carbonyl]-2,3-dihydro-
CAS110311-27-8
SynonymsLY 186641;N-(5-Indanylsulfonyl)-N'-(4-chlorophenyl)urea; N-[[(4-Chlorophenyl)amino]carbonyl]-2,3-dihydro-1H-indene-5-sulfonamide;NSC 642684; NSC 645012; NSC 656667; Sulofenur
Molecular FormulaC16H15 Cl N2 O3 S
Molecular Weight350.8199

refractive index1.656

CHEMICAL IDENTIFICATION

RTECS NUMBER :

NK8730000

CHEMICAL NAME :

1H-Indene-5-sulfonamide, 2,3-dihydro-N-(((4-chlorophenyl)amino)carbonyl)-

CAS REGISTRY NUMBER :

110311-27-8

LAST UPDATED :

199612

DATA ITEMS CITED :

4

MOLECULAR FORMULA :

C16-H15-Cl-N2-O3-S

MOLECULAR WEIGHT :

350.84

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>1 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 16,517,1991

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

>1 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 16,517,1991 ** REPRODUCTIVE DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

2940 mg/kg

SEX/DURATION :

male 14 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :

REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,47,1992

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

2940 mg/kg

SEX/DURATION :

male 14 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :

REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,47,1992