Piperazine,1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, hydrochloride(1:2) cas no:1104-22-9
Synonyms: Piperazine,1-(p-chloro-a-phenylbenzyl)-4-(m-methylbenzyl)-,dihydrochloride (6CI,8CI);Piperazine,1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride(9CI);1-(p-Chloro-a-phenylbenzyl)-4-(m-methylbenzyl)piperazine dihydrochloride;Ancolandihydrochloride;Bonamine;Diadril;Meclizine dihydrochloride;Meclizinehydrochloride;Meclozine dihydrochloride;Meclozine hydrochloride;NSC 28728;Navidoxine;Parachloramine dihydrochloride;Postafen;Postafene dihydrochloride;
NamePiperazine,1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, hydrochloride(1:2)
CAS1104-22-9
SynonymsPiperazine,1-(p-chloro-a-phenylbenzyl)-4-(m-methylbenzyl)-,dihydrochloride (6CI,8CI);Piperazine,1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride(9CI);1-(p-Chloro-a-phenylbenzyl)-4-(m-methylbenzyl)piperazine dihydrochloride;Ancolandihydrochloride;Bonamine;Diadril;Meclizine dihydrochloride;Meclizinehydrochloride;Meclozine dihydrochloride;Meclozine hydrochloride;NSC 28728;Navidoxine;Parachloramine dihydrochloride;Postafen;Postafene dihydrochloride;
EINECS(EC#)214-164-8
Molecular FormulaC25H29Cl3N2
Molecular Weight463.87
Appearancewhite,slightly yellowish,crystalline powder
storage temp2-8°C
Hazard Xn: Harmful;
Risk R22
Safety
Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
Hazard Codes: 
Xn
Risk Statements: 22-63
R22:Harmful if swallowed.
R63:Possible risk of harm to the unborn child.
Safety Statements: 22-36
S22:Do not breathe dust.
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: TL2005000
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD50 |
intraperitoneal |
625mg/kg (625mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: EXCITEMENT
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION |
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 43, Pg. 653, 1954. |
| mouse |
LD50 |
oral |
1600mg/kg (1600mg/kg) |
|
"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 67, 1969. |
