Bufa-20,22-dienolide,16-(acetyloxy)-14,15-epoxy-3,5-dihydroxy-, (3b,5b,15b,16b)- cas no:1108-68-5
Synonyms: 5b-Bufa-20,22-dienolide, 14,15b-epoxy-3b,5,16b-trihydroxy-, 16-acetate (8CI); Cinobufotalin (7CI);14,15-Epoxy-14H-cyclopenta[a]phenanthrene, bufa-20,22-dienolide deriv.; NSC90326
NameBufa-20,22-dienolide,16-(acetyloxy)-14,15-epoxy-3,5-dihydroxy-, (3b,5b,15b,16b)-
CAS1108-68-5
Synonyms5b-Bufa-20,22-dienolide, 14,15b-epoxy-3b,5,16b-trihydroxy-, 16-acetate (8CI); Cinobufotalin (7CI);14,15-Epoxy-14H-cyclopenta[a]phenanthrene, bufa-20,22-dienolide deriv.; NSC90326
Molecular FormulaC26H34 O7
Molecular Weight458.544
refractive index1.611
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(a)
Hazard T+: Very toxic;
Risk R26/27/28
Safety
Hazard Codes: 
T+
Risk Statements: 26/27/28
R26/27/28:Very toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-36/37/39-45
S22:Do not breathe dust.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2811 6.1/PG 1
WGK Germany: 3
RTECS: EI2991000
HazardClass: 6.1(a)
PackingGroup: II
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| cat |
LD50 |
intravenous |
200ug/kg (0.2mg/kg) |
|
"Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963Vol. -, Pg. 189, 1963. |
| cat |
LDLo |
unreported |
199ug/kg (0.199mg/kg) |
|
Pharmaceutica Acta Helvetiae. Vol. 24, Pg. 222, 1949. |
| mouse |
LD50 |
intravenous |
5150ug/kg (5.15mg/kg) |
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ANTIPSYCHOTIC |
Chemical and Pharmaceutical Bulletin. Vol. 24, Pg. 1714, 1976.
|
