Amlodipine besylate cas no:111470-99-6
Synonyms: Amlodipine benzenesulfonate;Monopina;Amlodin;Norvas;3,5-Pyridinedicarboxylic acid,2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)- 1,4-dihydro-6-methyl-,3-ethyl 5-methyl ester,monobenzenesulfonate;3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl-5-methyl ester, monobenzenesulfonate;Myodura;Amcard;Tensivask;Norvasc (TN);3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (+-)-, monobenzenesulfonate;Amdipin;Amlogard;Norvask;Antacal;3-Ethyl 5-methyl (+-)-2-((2-aminoethoxy)methyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate, monobenzenesulfonate;Terloc;Astudar;benzenesulfonic acid; ethyl methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate;Norvasc;Cordarene;Cardiorex;
NameAmlodipine besylate
CAS111470-99-6
SynonymsAmlodipine benzenesulfonate;Monopina;Amlodin;Norvas;3,5-Pyridinedicarboxylic acid,2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)- 1,4-dihydro-6-methyl-,3-ethyl 5-methyl ester,monobenzenesulfonate;3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl-5-methyl ester, monobenzenesulfonate;Myodura;Amcard;Tensivask;Norvasc (TN);3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (+-)-, monobenzenesulfonate;Amdipin;Amlogard;Norvask;Antacal;3-Ethyl 5-methyl (+-)-2-((2-aminoethoxy)methyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate, monobenzenesulfonate;Terloc;Astudar;benzenesulfonic acid; ethyl methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate;Norvasc;Cordarene;Cardiorex;
Molecular FormulaC20H25ClN2O5.C6H6O3S
Molecular Weight567.05094
AppearanceWhite powder
Hazard Xn: Harmful;
Risk R22
Safety
Hazard Codes:
Xn
Risk Statements: 22-36/37/38-20/21/22?
R22:Harmful if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS of Amlodipine besylate (CAS NO.111470-99-6): US7967700
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| dog |
LDLo |
oral |
10mg/kg (10mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: NAUSEA OR VOMITING |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 1169, 1994. |
| man |
TDLo |
oral |
1429ug/kg (1.429mg/kg) |
VASCULAR: SHOCK
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA |
American Journal of Emergency Medicine. Vol. 16, Pg. 527, 1998. |
| mouse |
LD50 |
intraperitoneal |
31mg/kg (31mg/kg) |
? |
Drugs in Japan Vol. -, Pg. 71, 1995. |
| mouse |
LD50 |
oral |
37mg/kg (37mg/kg) |
? |
Drugs in Japan Vol. -, Pg. 71, 1995. |
| mouse |
LD50 |
subcutaneous |
36mg/kg (36mg/kg) |
? |
Drugs in Japan Vol. -, Pg. 71, 1995. |
| rat |
LD50 |
intraperitoneal |
42mg/kg (42mg/kg) |
? |
Drugs in Japan Vol. -, Pg. 71, 1995. |
| rat |
LD50 |
oral |
393mg/kg (393mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BLOOD: OTHER CHANGES |
Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 177, 1991. |
| rat |
LD50 |
subcutaneous |
678mg/kg (678mg/kg) |
? |
Drugs in Japan Vol. -, Pg. 71, 1995. |
| women |
TDLo |
oral |
1mg/kg (1mg/kg) |
CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION |
Annals of Pharmacotherpy. Vol. 31, Pg. 853, 1997. |
| women |
TDLo |
unreported |
6mg/kg/60D-I (6mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION |
Lancet. Vol. 341, Pg. 1102, 1993. |
