111470-99-6|Amlodipine besylateProducts Supply - Chemical intermediates Network

Amlodipine besylate cas no:111470-99-6

Synonyms: Amlodipine benzenesulfonate;Monopina;Amlodin;Norvas;3,5-Pyridinedicarboxylic acid,2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)- 1,4-dihydro-6-methyl-,3-ethyl 5-methyl ester,monobenzenesulfonate;3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl-5-methyl ester, monobenzenesulfonate;Myodura;Amcard;Tensivask;Norvasc (TN);3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (+-)-, monobenzenesulfonate;Amdipin;Amlogard;Norvask;Antacal;3-Ethyl 5-methyl (+-)-2-((2-aminoethoxy)methyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate, monobenzenesulfonate;Terloc;Astudar;benzenesulfonic acid; ethyl methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate;Norvasc;Cordarene;Cardiorex;

Identification

NameAmlodipine besylate
CAS111470-99-6
SynonymsAmlodipine benzenesulfonate;Monopina;Amlodin;Norvas;3,5-Pyridinedicarboxylic acid,2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)- 1,4-dihydro-6-methyl-,3-ethyl 5-methyl ester,monobenzenesulfonate;3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl-5-methyl ester, monobenzenesulfonate;Myodura;Amcard;Tensivask;Norvasc (TN);3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (+-)-, monobenzenesulfonate;Amdipin;Amlogard;Norvask;Antacal;3-Ethyl 5-methyl (+-)-2-((2-aminoethoxy)methyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate, monobenzenesulfonate;Terloc;Astudar;benzenesulfonic acid; ethyl methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate;Norvasc;Cordarene;Cardiorex;
Molecular FormulaC₂₀H₂₅ClN₂O₅^.C₆H₆O₃S
Molecular Weight567.05094

Chemical Properties

AppearanceWhite powder

Safety Data

Hazard Xn: Harmful;
Risk R22
Safety

Hazard Codes: Harmful Xn
Risk Statements: 22-36/37/38-20/21/22?
R22:Harmful if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS of Amlodipine besylate (CAS NO.111470-99-6): US7967700

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	oral	10mg/kg (10mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: NAUSEA OR VOMITING	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 1169, 1994.
man	TDLo	oral	1429ug/kg (1.429mg/kg)	VASCULAR: SHOCK KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA	American Journal of Emergency Medicine. Vol. 16, Pg. 527, 1998.
mouse	LD50	intraperitoneal	31mg/kg (31mg/kg)	?	Drugs in Japan Vol. -, Pg. 71, 1995.
mouse	LD50	oral	37mg/kg (37mg/kg)	?	Drugs in Japan Vol. -, Pg. 71, 1995.
mouse	LD50	subcutaneous	36mg/kg (36mg/kg)	?	Drugs in Japan Vol. -, Pg. 71, 1995.
rat	LD50	intraperitoneal	42mg/kg (42mg/kg)	?	Drugs in Japan Vol. -, Pg. 71, 1995.
rat	LD50	oral	393mg/kg (393mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BLOOD: OTHER CHANGES	Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 177, 1991.
rat	LD50	subcutaneous	678mg/kg (678mg/kg)	?	Drugs in Japan Vol. -, Pg. 71, 1995.
women	TDLo	oral	1mg/kg (1mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION	Annals of Pharmacotherpy. Vol. 31, Pg. 853, 1997.
women	TDLo	unreported	6mg/kg/60D-I (6mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION	Lancet. Vol. 341, Pg. 1102, 1993.

supplier list

Molcan Corporation: Tel:905-731-5537, 905-731-6592, 1-888-237-7579; Address: 70 East Beaver Creek Road #39 Richmond Hill, Toronto, Ontario, Canada L4B 3B2

Hangzhou Starshine Pharmaceutical Co., LTD: Tel:86-571-8696517; Address: Fengqi East Road, Hangzhou, China.

Luna Chemicals Co.,Ltd.: Tel:; Address: 1502-1503,No.310 North Zhong Shan Rd., Hangzhou,China

Changzhou Yabang Pharmaceutical Co., LTD: Tel:; Address: 6# Liangchang Donglu, Jintan, Changzhou, Jiangsu, China

Gyma Laboratories Of America, Inc.: Tel:+1-516-933-0900; Address: 135 Cantiague Rock Rd.Westbury, NY 11590

Chemfar Ltd.: Tel:; Address: 16E,Huarong Times Mansion, No.3880 Jiangnan Avenue, Binjiang District, Hangzhou, China

JAI RADHE SALES: Tel:; Address: 309/310 HARIKRUPA TOWER,NR.OLD SHARDA MANDIR CHAR RASTA,ELLISBRIDGE ,AHMEDABAD,GUJRAT , INDIA.

La Nova Chem: Tel:+91-22-5692-1530/31/32; Address: E-404, Remi Biz Court,Veera Desai Road, Andheri (West),Mumbai - 400058, India.

Qilong Chemical Co., Ltd.: Tel:86-574-63858500; Address: No.586, Jiangnan Road,High-tech Park, Ningbo, Zhejiang 315040,

Hetero Drugs Ltd.,: Tel:+91-(40)-23704923; Address: H.No. 8-3-166/7/1, Erragadda, Hyderabad, Andhra Pradesh 500 018,

Matrix Laboratories Ltd.: Tel:+91-(40)-27700363; Address: 1-151/1, IV Floor, Sairam Towers, Alexander Road, Secunderabad, Andhra Pradesh 500 003,

Dr. Reddys Laboratories Ltd.: Tel:+91-(40)-2304 5439; Address: Bollaram Road,Miyapur, Hyderabad, Andhra Pradesh 500 049,

Sudharsan Laboratories Limited.: Tel:+91-(40)-23544795, 23544885; Address: Plot No.1072, Road No.44, Jubilee Hills, Hyderabad, Andhra Pradesh 500 033,

Praveen Laboratories Pvt. Ltd.: Tel:+91-(261)-2622816, 2638867; Address: G-114/115, Vakharia Market, Ring Road, Surat, Gujarat 395 002,

Smruthi Organics Ltd.: Tel:+91-(217)-231 0267, 231 0367; Address: 165A Balaji Bhavan, Railway Lines, Solapur, Maharashtra 413001,

Amlodipine besylate cas no:111470-99-6

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