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chlorphenamine hydrogen maleate cas no:113-92-8

Synonyms: CHLORPHENIRAMINE MALEATE; Chloropheniramine maleate

Identification

Namechlorphenamine hydrogen maleate
CAS113-92-8
SynonymsCHLORPHENIRAMINE MALEATE; Chloropheniramine maleate
EINECS(EC#)204-037-5
Molecular FormulaC16H19ClN2?C4H4O4;C20H
Molecular Weight390.86

Chemical Properties

AppearanceOdorless white crystalline solid or white powder with a bitter taste.
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard T:Toxic
Risk R25
Safety

Poison by ingestion, intravenous, and subcutaneous routes. Experimental reproductive effects. Used as an antihistamine. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl^? and NO_x.
Hazard Codes:? Toxic T
Risk Statements: 25?
R25: Toxic if swallowed.
Safety Statements: 36/37/39-45?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: US6504000
HazardClass: 6.1(b)
PackingGroup of Chlorpheniramine maleate (CAS NO.113-92-8): III

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	75mg/kg (75mg/kg)	?	Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
dog	LD50	intravenous	97600ug/kg (97.6mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.
guinea pig	LD50	intravenous	68mg/kg (68mg/kg)	?	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 313, 1958.
guinea pig	LD50	oral	198mg/kg (198mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.
guinea pig	LD50	subcutaneous	101mg/kg (101mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.
mouse	LD50	intraperitoneal	76700ug/kg (76.7mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.
mouse	LD50	intravenous	26100ug/kg (26.1mg/kg)	?	Toxicology and Applied Pharmacology. Vol. 23, Pg. 537, 1972.
mouse	LD50	oral	130mg/kg (130mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1644, 1978.
mouse	LD50	subcutaneous	104mg/kg (104mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.
rat	LD50	oral	306mg/kg (306mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 1371, 1978.
rat	LD50	subcutaneous	365mg/kg (365mg/kg)	?	Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.

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