Potassium benzylpenicillin cas no:113-98-4
Synonyms: 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-, monopotassium salt (8CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-[2S-(2a,5a,6b)]-, monopotassium salt;Penicillin G, potassium salt (7CI);Benzylpenicillin potassium;Benzylpenicillin potassium salt;Benzylpenicillinic acid potassium salt;Cosmopen;Monopen;NSC 131815;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]- (2S,5R,6R)-, potassium salt(1:1);Potassium 2,2-dimethyl-6b-phenylacetamidopenam-3a-carboxylate;Potassium6-(phenylacetamido)penicillanate;Potassiumbenzylpenicillinate;
NamePotassium benzylpenicillin
CAS113-98-4
Synonyms4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-, monopotassium salt (8CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-[2S-(2a,5a,6b)]-, monopotassium salt;Penicillin G, potassium salt (7CI);Benzylpenicillin potassium;Benzylpenicillin potassium salt;Benzylpenicillinic acid potassium salt;Cosmopen;Monopen;NSC 131815;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]- (2S,5R,6R)-, potassium salt(1:1);Potassium 2,2-dimethyl-6b-phenylacetamidopenam-3a-carboxylate;Potassium6-(phenylacetamido)penicillanate;Potassiumbenzylpenicillinate;
EINECS(EC#)204-038-0
Molecular FormulaC16H17KN2O4S
Molecular Weight334.39012
Appearancewhite to off-white crystalline powder
refractive index294 ° (C=1, H2O)
storage temp2-8°C
Hazard Xn:;
Risk R42/43
Safety Hazard Codes:Xn,C,F
Risk Statements:42/43-34-11
42/43:May cause sensitization by inhalation and skin contact
34:Causes burns
11:Highly Flammable
Safety Statements:36/37-45-36/37/39-26-16
36/37:Wear suitable protective clothing and gloves
45:In case of accident or if you feel unwell, seek medical
advice immediately (show label where possible)
36/37/39:Wear suitable protective clothing, gloves and eye/face
protection
26:In case of contact with eyes, rinse immediately with plenty
of water and seek medical advice
16:Keep away from sources of ignition - No smoking
WGK Germany:2
HS Code:29411000
HS Code 29411000
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XH9700000
- CHEMICAL NAME :
- 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,
3,3-dimethyl-7-oxo-6- (2-phenylacetamido)-,
monopotassium salt
- CAS REGISTRY NUMBER :
- 113-98-4
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 21
- MOLECULAR FORMULA :
- C16-H17-N2-O4-S.K
- MOLECULAR WEIGHT :
- 372.51
- WISWESSER LINE NOTATION :
- T45 ANV ESTJ CMV1R& F1 F1 GVQ &-KA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8900 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 11250 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 243 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6257 mg/kg
- TOXIC EFFECTS :
- Behavioral - excitement
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 240 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intracerebral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 5848 mg/kg
- TOXIC EFFECTS :
- Behavioral - hallucinations, distorted perceptions
Lungs, Thorax, or Respiration - respiratory depression
Nutritional and Gross Metabolic - body temperature decrease
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 382 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - ulceration or bleeding from stomach
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 374 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 303 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1180 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 312 mg/kg/14W-I
- TOXIC EFFECTS :
- Gastrointestinal - changes in pancreatic weight
Kidney, Ureter, Bladder - changes in bladder weight
Related to Chronic Data - death
MUTATION DATA
- TEST SYSTEM :
- Rodent - rat
- DOSE/DURATION :
- 200 mg/kg/8D
- REFERENCE :
- JOURAA Journal of Urology. (Williams & Wilkins Co., 428 E. Preston St.,
Baltimore, MD 21202) V.1- 1917- Volume(issue)/page/year: 112,348,1974
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81952
No. of Facilities: 1261 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 3510 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81952
No. of Facilities: 504 (estimated)
No. of Industries: 3
No. of Occupations: 10
No. of Employees: 27005 (estimated)
No. of Female Employees: 20458 (estimated)