1134-47-0|BaclofenProducts Supply - Chemical intermediates Network

Baclofen cas no:1134-47-0

Synonyms: (+/-)-beta(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal; 4-amino-3-(4-chlorophenyl)butyric acid; Atrofen; beta-(4-chlorophenyl)gaba; beta-(4-chlorophenyl)-gamma-aminobutyric acid; ba 34647; baclon; beta-(aminomethyl)-4-chlorobenzenepropanoic acid; beta-(aminomethyl)-p-chlorohydrocinnamic acid; c 34647ba; ciba 34,647-ba; Lioresal; gamma-amino-beta-(p-chlorophenyl)butyric acid

Identification

NameBaclofen
CAS1134-47-0
Synonyms(+/-)-beta(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal; 4-amino-3-(4-chlorophenyl)butyric acid; Atrofen; beta-(4-chlorophenyl)gaba; beta-(4-chlorophenyl)-gamma-aminobutyric acid; ba 34647; baclon; beta-(aminomethyl)-4-chlorobenzenepropanoic acid; beta-(aminomethyl)-p-chlorohydrocinnamic acid; c 34647ba; ciba 34,647-ba; Lioresal; gamma-amino-beta-(p-chlorophenyl)butyric acid
EINECS(EC#)214-486-9
Molecular FormulaC10H12ClNO2
Molecular Weight213.66

Chemical Properties

Appearancewhite to very faintly yellow solid
refractive index1.576
storage temp2-8°C

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard T:Toxic;
Risk R61;R25;R36/37/38;R42/43
Safety

Poison by ingestion, subcutaneous and intravenous routes. Human systemic effects by ingestion: blood pressure lowering, coma, muscle weakness, pulse rate decrease, respiratory depression. When heated to decomposition it emits toxic fumes of Cl⁻ and NO_x. A muscle relaxant.
Safety Information of Baclofen (CAS NO.1134-47-0)
Hazard Codes: T,Xn
Risk Statements: 61-25-36/37/38-42/43-20/21/22
R61:May cause harm to the unborn child.
R25 :Toxic if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R42/43:May cause sensitization by inhalation and skin contact.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 53-22-36/37/39-45-52-26
S53:Avoid exposure - obtain special instructions before use.
S22:Do not breathe dust.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S52:Not recommended for interior use on large surface areas.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: MW5084200
HazardClass: 6.1(b)
PackingGroup: III

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	571ug/kg (0.571mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Annals of Pharmacotherpy. Vol. 27, Pg. 883, 1993.
man	TDLo	oral	4286ug/kg (4.286mg/kg)	BEHAVIORAL: COMA CARDIAC: PULSE RATE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	American Journal of Emergency Medicine. Vol. 4, Pg. 552, 1986.
man	TDLo	oral	14mg/kg (14mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: COMA	Journal of Toxicology, Clinical Toxicology. Vol. 20, Pg. 59, 1983.
man	TDLo	oral	3429mg/kg (3429mg/kg)	BEHAVIORAL: COMA CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION	Journal of Toxicology, Clinical Toxicology. Vol. 32, Pg. 291, 1994.
man	TDLo	unreported	857ug/kg/2D-I (0.857mg/kg)	BRAIN AND COVERINGS: CHANGES IN SURFACE EEG BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	Italian Journal of Neurological Sciences. Vol. 12, Pg. 323, 1991.
mouse	LD50	intravenous	31mg/kg (31mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2069, 1979.
mouse	LD50	oral	200mg/kg (200mg/kg)		Drugs in Japan Vol. 6, Pg. 576, 1982.
mouse	LD50	subcutaneous	103mg/kg (103mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 181, 1980.
rat	LD50	intravenous	78mg/kg (78mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 181, 1980.
rat	LD50	oral	145mg/kg (145mg/kg)		Drugs in Japan Vol. 6, Pg. 576, 1982.
rat	LD50	subcutaneous	115mg/kg (115mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 181, 1980.
women	TDLo	oral	8mg/kg (8mg/kg)	CARDIAC: PULSE RATE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Postgraduate Medical Journal. Vol. 57, Pg. 580, 1981.
women	TDLo	oral	9mg/kg (9mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Postgraduate Medical Journal. Vol. 56, Pg. 865, 1980.
women	TDLo	oral	18mg/kg (18mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Journal of Toxicology, Clinical Toxicology. Vol. 22, Pg. 11, 1984.
women	TDLo	parenteral	25ug/kg/2D-I (0.025mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: COMA	International Journal of Clinical Pharmacology, Therapy and Toxicology. Vol. 29, Pg. 274, 1991.

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Baclofen cas no:1134-47-0

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