114-07-8|ErythromycinProducts Supply - Chemical intermediates Network

Erythromycin cas no:114-07-8

Synonyms: Abomacetin; Ak-Mycin; Aknin; Drmysin; E-Base; E.E.S; Emgel; EMU; E-mycin; Ergel; Eritocina; Eritrocina; Erthrogran; Eryacne; ERYC; Erycen; Erycette; Erycin; Erycinum; Ery Derm; Erymax; Erypar; ERY-PED; ERY-TAB; Erythro; Erythrocin; Erythroguent; Erythromast; Erythromast 36; Erythromid; Gallimycin; Ilocap; Ilosone; Ilotycin; Inderm; L-alpha-Egg-phosphatidylcholine; P.C.E.; Pediamycin; Retcin; Robimycin; Statcin; Staticin; Stiemycin; Torlamicina; Torlamicna; T-Stat; USP; Wintrocin; Wyamycin-s

Identification

NameErythromycin
CAS114-07-8
SynonymsAbomacetin; Ak-Mycin; Aknin; Drmysin; E-Base; E.E.S; Emgel; EMU; E-mycin; Ergel; Eritocina; Eritrocina; Erthrogran; Eryacne; ERYC; Erycen; Erycette; Erycin; Erycinum; Ery Derm; Erymax; Erypar; ERY-PED; ERY-TAB; Erythro; Erythrocin; Erythroguent; Erythromast; Erythromast 36; Erythromid; Gallimycin; Ilocap; Ilosone; Ilotycin; Inderm; L-alpha-Egg-phosphatidylcholine; P.C.E.; Pediamycin; Retcin; Robimycin; Statcin; Staticin; Stiemycin; Torlamicina; Torlamicna; T-Stat; USP; Wintrocin; Wyamycin-s
EINECS(EC#)204-040-1
Molecular FormulaC37H67NO13
Molecular Weight733.92678

Chemical Properties

AppearanceFluffy colorless powder
alpha-74.5 o (C=2, ETHANOL)
refractive index-74 ° (C=2, EtOH)
storage temp0-6°C

Safety Data

Hazard Xn:Harmful
Risk R42/43
Safety

Poison by intravenous and intramuscular routes. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes:? Harmful Xn, Irritant Xi
Risk Statements: 42/43-36/37/38?
R42/43:May cause sensitization by inhalation and skin contact.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 45-37-24-36-26?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S37:Wear suitable gloves.?
S24:Avoid contact with skin.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.
WGK Germany: 2
RTECS of Erythromycin (CAS NO.114-07-8): KF4375000

HS Code 29415000

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	10mg/kg/1D-I (10mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Annals of Internal Medicine. Vol. 115, Pg. 69, 1991.
child	TDLo	oral	250mg/kg (250mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: OTHER CHANGES BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT	Pediatrics. Vol. 90, Pg. 624, 1992.
dog	LDLo	unreported	> 100mg/kg (100mg/kg)	?	Antibiotics and Chemotherapy Vol. 2, Pg. 281, 1952.
guinea pig	LD50	intraperitoneal	413mg/kg (413mg/kg)	?	Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 41, Pg. 555, 1952.
hamster	LD50	oral	3018mg/kg (3018mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 41, Pg. 555, 1952.
mouse	LD50	intramuscular	394mg/kg (394mg/kg)	?	Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 44, Pg. 199, 1955.
mouse	LD50	intraperitoneal	280mg/kg (280mg/kg)	?	Journal of Antibiotics. Vol. 43, Pg. 938, 1990.
mouse	LD50	intravenous	426mg/kg (426mg/kg)	?	"Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 273, 1967.
mouse	LD50	oral	2580mg/kg (2580mg/kg)	?	Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 31, Pg. 241, 1974.
mouse	LD50	subcutaneous	1800mg/kg (1800mg/kg)	?	Antibiotics and Chemotherapy Vol. 2, Pg. 281, 1952.
rat	LD50	oral	4600mg/kg (4600mg/kg)	?	Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 31, Pg. 241, 1974.
rat	LDLo	subcutaneous	427mg/kg (427mg/kg)	?	Compilation of LD50 Values of New Drugs.

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Erythromycin cas no:114-07-8

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