child |
TDLo |
oral |
10mg/kg/1D-I (10mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Annals of Internal Medicine. Vol. 115, Pg. 69, 1991. |
child |
TDLo |
oral |
250mg/kg (250mg/kg) |
GASTROINTESTINAL: NAUSEA OR VOMITING
GASTROINTESTINAL: OTHER CHANGES
BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT |
Pediatrics. Vol. 90, Pg. 624, 1992. |
dog |
LDLo |
unreported |
> 100mg/kg (100mg/kg) |
? |
Antibiotics and Chemotherapy Vol. 2, Pg. 281, 1952. |
guinea pig |
LD50 |
intraperitoneal |
413mg/kg (413mg/kg) |
? |
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 41, Pg. 555, 1952. |
hamster |
LD50 |
oral |
3018mg/kg (3018mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 41, Pg. 555, 1952. |
mouse |
LD50 |
intramuscular |
394mg/kg (394mg/kg) |
? |
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 44, Pg. 199, 1955. |
mouse |
LD50 |
intraperitoneal |
280mg/kg (280mg/kg) |
? |
Journal of Antibiotics. Vol. 43, Pg. 938, 1990. |
mouse |
LD50 |
intravenous |
426mg/kg (426mg/kg) |
? |
"Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 273, 1967. |
mouse |
LD50 |
oral |
2580mg/kg (2580mg/kg) |
? |
Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 31, Pg. 241, 1974. |
mouse |
LD50 |
subcutaneous |
1800mg/kg (1800mg/kg) |
? |
Antibiotics and Chemotherapy Vol. 2, Pg. 281, 1952. |
rat |
LD50 |
oral |
4600mg/kg (4600mg/kg) |
? |
Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 31, Pg. 241, 1974. |
rat |
LDLo |
subcutaneous |
427mg/kg (427mg/kg) |
? |
Compilation of LD50 Values of New Drugs. |