Neostigmine bromide cas no:114-80-7
Synonyms: (m-Hydroxyphenyl)trimethylammoniumbromide, dimethylcarbamate (7CI);Ammonium, (m-hydroxyphenyl)trimethyl-,bromide, dimethylcarbamate (8CI);Benzenaminium,3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-, bromide (9CI);Neostigminebromide (6CI);Carbamic acid, dimethyl-, ester with(m-hydroxyphenyl)trimethylammonium bromide (8CI);(3-Dimethylcarbamoyloxyphenyl)trimethylammonium bromide;Eustigmin bromide;Kirkstigmine bromide;Neoesserin;Philostigmin bromide;Prostigmin bromide;Prostigmine bromide;Stigmanol bromide;
NameNeostigmine bromide
CAS114-80-7
Synonyms(m-Hydroxyphenyl)trimethylammoniumbromide, dimethylcarbamate (7CI);Ammonium, (m-hydroxyphenyl)trimethyl-,bromide, dimethylcarbamate (8CI);Benzenaminium,3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-, bromide (9CI);Neostigminebromide (6CI);Carbamic acid, dimethyl-, ester with(m-hydroxyphenyl)trimethylammonium bromide (8CI);(3-Dimethylcarbamoyloxyphenyl)trimethylammonium bromide;Eustigmin bromide;Kirkstigmine bromide;Neoesserin;Philostigmin bromide;Prostigmin bromide;Prostigmine bromide;Stigmanol bromide;
EINECS(EC#)204-054-8
Molecular FormulaC12H19BrN2O2
Molecular Weight303.24
Appearancewhite powder
storage temp-20?C Freezer
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(a)
Hazard T: Toxic;T+: Very toxic;
Risk R25;R36/37/38;R42/43
Safety
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of Br−, NH3, and NOx. See also CARBAMATES and BROMIDES.
Safety Information of Neostigmine bromide (CAS NO.114-80-7):
Hazard Codes: T+.gif)
,T
Risk Statements:
25: Toxic if swallowed
26: Very Toxic by inhalation
27: Very Toxic in contact with skin
28: Very Toxic if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
42: May cause sensitization by inhalation
43: May cause sensitization by skin contact
Safety Statements:
22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
28A : After contact with skin, wash immediately with plenty of water.
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
| 1. |
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orl-rat LD50:51 mg/kg
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PSEBAA Proceedings of the Society for Experimental Biology and Medicine. 120 (1965),511. |
| 2. |
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ipr-rat LDLo:835 µg/kg
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JPETAB Journal of Pharmacology and Experimental Therapeutics. 136 (1962),20. |
| 3. |
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scu-rat LD50:370 µg/kg
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JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. 39 (1950),701. |
| 4. |
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ivn-rat LD50:165 µg/kg
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JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. 39 (1950),701. |
| 5. |
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orl-mus LD50:7 mg/kg
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PSEBAA Proceedings of the Society for Experimental Biology and Medicine. 120 (1965),511. |
| 6. |
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ipr-mus LD50:610 µg/kg
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JPMSAE Journal of Pharmaceutical Sciences. 57 (1968),172. |
| 7. |
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scu-mus LD50:420 µg/kg
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JPETAB Journal of Pharmacology and Experimental Therapeutics. 99 (1950),16. |
| 8. |
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ivn-mus LD50:130 µg/kg
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PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. 16 (1982),164. |
