114798-26-4|LosartanProducts Supply - Chemical intermediates Network

Losartan cas no:114798-26-4

Synonyms: 2-n-butyl-4-chloro-5-hydroxymethyl-1-[[2-(1H-tetrazol-5-yl)-biphenyl-4-yl]methyl]imidazole;DUP 89;1H-imidazole-5-methanol, 2-butyl-4-chloro-1-[[2-(2H-tetrazol-5-yl)[1,1-biphenyl]-4-yl]methyl]-;[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol;2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5ylphenyl)benzyl]imidazole-5-methanol;2-Butyl-4-chloro-1-[[2-(1H-tetrazol-5-yl)[1,1-biphenyl]-4-yl]methyl-1H-imidazole-5-methanol;

Identification

NameLosartan
CAS114798-26-4
Synonyms2-n-butyl-4-chloro-5-hydroxymethyl-1-[[2-(1H-tetrazol-5-yl)-biphenyl-4-yl]methyl]imidazole;DUP 89;1H-imidazole-5-methanol, 2-butyl-4-chloro-1-[[2-(2H-tetrazol-5-yl)[1,1-biphenyl]-4-yl]methyl]-;[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol;2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5ylphenyl)benzyl]imidazole-5-methanol;2-Butyl-4-chloro-1-[[2-(1H-tetrazol-5-yl)[1,1-biphenyl]-4-yl]methyl-1H-imidazole-5-methanol;
Molecular FormulaC₂₂H₂₃ClN₆O
Molecular Weight422.92

Chemical Properties

Appearancepale yellow solid
refractive index1.68

Safety Data

Hazard Xi: Irritant;
Risk R36/37/38
Safety

Hazard Codes:? Irritant Xi
Risk Statements: 36/37/38?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	7mg/kg/1W-I (7mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE LUNGS, THORAX, OR RESPIRATION: COUGH GASTROINTESTINAL: OTHER CHANGES	Annals of Internal Medicine. Vol. 129, Pg. 72, 1998.
man	TDLo	oral	17500ug/kg/17 (17.5mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE	Lancet. Vol. 347, Pg. 471, 1996. ?
man	TDLo	oral	18mg/kg/13W-I (18mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE	Annals of Internal Medicine. Vol. 129, Pg. 72, 1998.
man	TDLo	oral	21429ug/kg/30 (21.429mg/kg)	?	JAMA, Journal of the American Medical Association. Vol. 278, Pg. 1572, 1997. ?
man	TDLo	oral	21429ug/kg/30 (21.429mg/kg)	LIVER: LIVER FUNCTION TESTS IMPAIRED LIVER: OTHER CHANGES	JAMA, Journal of the American Medical Association. Vol. 278, Pg. 1572, 1997. ?
women	TDLo	oral	42mg/kg/6W-I (42mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED	Annals of Internal Medicine. Vol. 124, Pg. 775, 1996.

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Losartan cas no:114798-26-4

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