114977-28-5|DocetaxelProducts Supply - Chemical intermediates Network

Docetaxel cas no:114977-28-5

Synonyms: Benzenepropanoicacid, b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxy-,12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylester, [2aR-[2aa,4b,4ab,6b,9a(aR*,bS*),11a,12a,12aa,12ba]]-;Docetaxel Winthrop;Docetaxol;Docetaxolum;HSDB 6965;RP 56976;Taxotere;

Identification

NameDocetaxel
CAS114977-28-5
SynonymsBenzenepropanoicacid, b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxy-,12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylester, [2aR-[2aa,4b,4ab,6b,9a(aR*,bS*),11a,12a,12aa,12ba]]-;Docetaxel Winthrop;Docetaxol;Docetaxolum;HSDB 6965;RP 56976;Taxotere;
Molecular FormulaC₄₃H₅₃NO₁₄
Molecular Weight807.88

Chemical Properties

AppearanceOff-white Cryst.
alpha-36 o (C=0.74,ETOH)
refractive index1.618
storage tempKeep tightly closed. Store at +4°C.

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard Xi:Irritant
Risk R36/37/38
Safety Hazard Codes:Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37: Wear suitable protective clothing and gloves.
RIDADR: 1544
RTECS: DA4172750
HazardClass: 6.1(b)
PackingGroup: III

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	2500ug/kg (2.5mg/kg)		Seminars in Oncology. Vol. 22(Suppl,
man	TDLo	intravenous	24mg/kg/9W-I (24mg/kg)	PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE PERIPHERAL NERVE AND SENSATION: PARESTHESIS BEHAVIORAL: MUSCLE WEAKNESS	Annals of Oncology. Vol. 8, Pg. 187, 1997.
mouse	LD50	intravenous	156mg/kg (156mg/kg)		Seminars in Oncology. Vol. 22(Suppl,
rat	LDLo	intravenous	20mg/kg (20mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 39, Pg. 659, 1997

supplier list

BioGin Biochemicals Co.,Ltd: Tel:; Address: No.9, Section 4, Ren Min Nan Road Chengdu, Sichuan,China

Shanghai Mingdou Chemical Co.,Ltd: Tel:86-21-52912919; Address: Floor 12th, Zhenyuan Building ,No 2052.North Zhongshan Road, Shanghai,China

Sinoway Chemical Co., Ltd.: Tel:; Address: 16/F,Huicheng Comm,Complex,No839 XiaHe Rd, Xiamen,China

Pharmasi Chemicals Co.,Ltd: Tel:; Address: Room 205, Renlesancun50-29,songjiang,shanghai,China

SUZHOU UNITE PHARMACEUTICAL CO.,LTD.: Tel:86-512-87666020; Address: ROOM NO.101,B BUILDING ,NO.31 NORTH DONGWU ROAD SUZHOU CHINA

Hwasun Biotechnology Co., Ltd.: Tel:; Address: Rm.505, Bldg. 2,No. 245 Jiachuan RD. Xuhui Dist.,200237, Shanghai, China

Luna Chemicals Co.,Ltd.: Tel:; Address: 1502-1503,No.310 North Zhong Shan Rd., Hangzhou,China

Zhejiang Medicines & Health Products Import & Exp...: Tel:; Address: ZMC Building,101-2 N. Zhongshan Road,Hangzhou,China.

Ancheng Pharma Limited: Tel:+86-755-82713308; Address: Flat 1812, 18/F., Min Hua Building, 7 Jing Tian Bei Steet, Futian District,Shenzhen,China

Depew Fine Chemical Co.,Ltd.: Tel:+86-571-87630650, 87630656, 87630657; Address: Room 202,No.317 Wantang Road,Hangzhou,China

Beijing Sinowall Science & Technology Co.,Ltd.: Tel:; Address: Room210,East Build 9,NO.83 Fuxing Road,Haidian District, Beijing

Sunji & Co., Ltd.: Tel:86-755-8825 1355 /1365 /1379; Address: Room 2103-2104, Block C , Huangdu Plaza, 3008 Yitian Road, Shenzhen 518048, P.R. of China

Hangzhou Pharma & Chem Co.,Ltd.: Tel:+86-571-87040515; Address: Rm.1201,QinglianBldg.No,139QingchunRd,HangzhouCity,Zhejiang,China

Suzhou Chontech Pharmachem Technology Co.,Ltd.: Tel:+86-512-66561568; Address: 77 Jinfeng Road(M.),Suzhou, 215101 China

Aliapharm: Tel:+49 69 971412-0; Address: AliaPharm GmbH Frankfurt Niedenau 49 60325 Frankfurt / Main

Docetaxel cas no:114977-28-5

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