Docetaxel cas no:114977-28-5
Synonyms: Benzenepropanoicacid, b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxy-,12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylester, [2aR-[2aa,4b,4ab,6b,9a(aR*,bS*),11a,12a,12aa,12ba]]-;Docetaxel Winthrop;Docetaxol;Docetaxolum;HSDB 6965;RP 56976;Taxotere;
NameDocetaxel
CAS114977-28-5
SynonymsBenzenepropanoicacid, b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxy-,12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylester, [2aR-[2aa,4b,4ab,6b,9a(aR*,bS*),11a,12a,12aa,12ba]]-;Docetaxel Winthrop;Docetaxol;Docetaxolum;HSDB 6965;RP 56976;Taxotere;
Molecular FormulaC43H53NO14
Molecular Weight807.88
AppearanceOff-white Cryst.
alpha-36 o (C=0.74,ETOH)
refractive index1.618
storage tempKeep tightly closed. Store at +4°C.
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Hazard Xi:Irritant
Risk R36/37/38
Safety Hazard Codes:
Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37: Wear suitable protective clothing and gloves.
RIDADR: 1544
RTECS: DA4172750
HazardClass: 6.1(b)
PackingGroup: III
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| dog |
LD50 |
intravenous |
2500ug/kg (2.5mg/kg) |
|
Seminars in Oncology. Vol. 22(Suppl, |
| man |
TDLo |
intravenous |
24mg/kg/9W-I (24mg/kg) |
PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE
PERIPHERAL NERVE AND SENSATION: PARESTHESIS
BEHAVIORAL: MUSCLE WEAKNESS |
Annals of Oncology. Vol. 8, Pg. 187, 1997. |
| mouse |
LD50 |
intravenous |
156mg/kg (156mg/kg) |
|
Seminars in Oncology. Vol. 22(Suppl, |
| rat |
LDLo |
intravenous |
20mg/kg (20mg/kg) |
|
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 39, Pg. 659, 1997 |
