Morphinan-6-one,7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, (9a,13a,14a)- cas no:115-53-7
Synonyms: 7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-9-alpha,13-alpha,14-alpha-morphinan-6-one;BRN 0095280;CCRIS 1550;Coculine;Cucoline;Kukoline;Sabianine A;Sinomenine;
NameMorphinan-6-one,7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, (9a,13a,14a)-
CAS115-53-7
Synonyms7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-9-alpha,13-alpha,14-alpha-morphinan-6-one;BRN 0095280;CCRIS 1550;Coculine;Cucoline;Kukoline;Sabianine A;Sinomenine;
EINECS(EC#)204-094-6
Molecular FormulaC19H23NO4
Molecular Weight329.38
AppearanceWhite powder
refractive index
storage tempKeep tightly closed. Store in a cool dry place.
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Hazard T: Toxic;
Risk R45
Safety
Safety Information of Morphinan-6-one,7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, (9a,13a,14a)- (CAS NO.115-53-7):
Hazard Codes: 
T
Risk Statements: 45-46-23/24/25-36/37/38-20/21/22
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
R45: May cause cancer.
R46: May cause heritable genetic damage.
Safety Statements: 53-22-26-36/37/39-45
S22: Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S53: Avoid exposure - obtain special instructions before use.
RIDADR: 1544
WGK Germany: 3
RTECS: QD2170000
F: 9
HazardClass: 6.1(b)
PackingGroup: III
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD50 |
intraperitoneal |
285mg/kg (285mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. Vol. 8, Pg. 177, 1960. |
| mouse |
LD50 |
oral |
580mg/kg (580mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. Vol. 10, Pg. 673, 1963. |
