N-Cbz-L-Phenylalanine cas no:1161-13-3

NameN-Cbz-L-Phenylalanine
CAS1161-13-3
Synonyms(Benzyloxycarbonyl)phenylalanine;(2S)-3-phenyl-2-phenylmethoxycarbonylamino-propanoic acid;Alanine, N-carboxy-3-phenyl-, N-benzyl ester, L-;N-((Phenylmethoxy)carbonyl)-L-phenylalanine;3-phenyl-2-phenylmethoxycarbonylamino-propanoic acid;L-N-Carboxy-3-phenylalanine N-benzyl ester;Z-L-Phe-OH;Z-PHE-OH;CBZ-L-Phenylalanine;CBZ-L-Phe-OH;Cbz-Phe-OH;Z-L-Phenylalanine;N-Carbobenzyloxy-L-Phenylalanine;N-Z-L-Phenylalanine;N-Benzyloxycarbonyl-L-phenylalanine;
EINECS(EC#)214-599-3
Molecular FormulaC₁₇H₁₇NO₄
Molecular Weight299.32

Appearancewhite amorphous powder
alpha5 o (C=5,ACETIC ACID)
refractive index5.3 ° (C=4, AcOH)
storage tempStore at RT.

Hazard Xn
Risk R62
Safety Poison by intravaginal route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

AY4343000

CHEMICAL NAME :

Alanine, N-carboxy-3-phenyl-, N-benzyl ester, L-

CAS REGISTRY NUMBER :

1161-13-3

LAST UPDATED :

199206

DATA ITEMS CITED :

4

MOLECULAR FORMULA :

C17-H17-N-O4

MOLECULAR WEIGHT :

299.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

251 mg/kg

TOXIC EFFECTS :

Tumorigenic - active as anti-cancer agent

REFERENCE :

JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 67,1726,1978

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravaginal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

250 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

280 mg/kg

SEX/DURATION :

female 28 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :

JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravaginal

DOSE :

280 mg/kg

SEX/DURATION :

female 28 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :

JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979