2H-1,4-Benzodiazepin-2-one,7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-,hydrochloride (1:2) cas no:1172-18-5
Synonyms: 2H-1,4-Benzodiazepin-2-one,7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-,dihydrochloride (9CI); 2H-1,4-Benzodiazepin-2-one,7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-1,3-dihydro-,dihydrochloride (7CI,8CI); 7-Chloro-1-(2-diethylaminoethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-onedihydrochloride;7-Chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-onedihydrochloride; Benozil; Dalmadorm; Dalmane; Dalmate; Dormodor; Felson;Flurazepam dihydrochloride; Flurazepam hydrochloride; ID 480; Insumin; Lunipax;NSC 78559; Ro 5-6901; Somlan
Name2H-1,4-Benzodiazepin-2-one,7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-,hydrochloride (1:2)
CAS1172-18-5
Synonyms2H-1,4-Benzodiazepin-2-one,7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-,dihydrochloride (9CI); 2H-1,4-Benzodiazepin-2-one,7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-1,3-dihydro-,dihydrochloride (7CI,8CI); 7-Chloro-1-(2-diethylaminoethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-onedihydrochloride;7-Chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-onedihydrochloride; Benozil; Dalmadorm; Dalmane; Dalmate; Dormodor; Felson;Flurazepam dihydrochloride; Flurazepam hydrochloride; ID 480; Insumin; Lunipax;NSC 78559; Ro 5-6901; Somlan
EINECS(EC#)214-630-0
Molecular FormulaC21H23 Cl F N3 O . 2 Cl H
Molecular Weight460.84
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Hazard Xn: Harmful;
Risk R22
Safety
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Habituating and possibly addictive. An hypnotic and sedative. When heated to decomposition it emits very toxic fumes of F−, NOx, and Cl−.
Safety Information of Dalmane (CAS NO.1172-18-5):
Hazard Codes: Xn.gif)
Risk Statements: 22-33
22: Harmful if swallowed
33: Danger of cumulative effects
Safety Statements: 1/2-22-36-36/37/39
1: Keep locked up
2: Keep out of the reach of children
22: Do not breathe dust
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD50 |
intraperitoneal |
186mg/kg (186mg/kg) |
|
Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975. |
| mouse |
LD50 |
intravenous |
59100ug/kg (59.1mg/kg) |
|
Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975. |
| mouse |
LD50 |
oral |
596mg/kg (596mg/kg) |
|
Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975. |
| mouse |
LD50 |
subcutaneous |
440mg/kg (440mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: ATAXIA
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) |
Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977. |
| rabbit |
LD50 |
oral |
568mg/kg (568mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 178, Pg. 216, 1969. |
| rat |
LD50 |
intraperitoneal |
152mg/kg (152mg/kg) |
|
Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975. |
| rat |
LD50 |
intravenous |
38700ug/kg (38.7mg/kg) |
|
Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975. |
| rat |
LD50 |
oral |
879mg/kg (879mg/kg) |
|
Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975. |
| rat |
LD50 |
subcutaneous |
859mg/kg (859mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 706, 1982. |
