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Tazarotene cas no:118292-40-3

Synonyms: 3-Pyridinecarboxylic acid,6-[(3,4-dihydro-4,4-dimethyl-2H-1- benzothiopyran-6-yl)ethynyl]-,ethyl ester;Ethyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate;Tazorac;Zorac;AGN 190168;

Identification
NameTazarotene
CAS118292-40-3
Synonyms3-Pyridinecarboxylic acid,6-[(3,4-dihydro-4,4-dimethyl-2H-1- benzothiopyran-6-yl)ethynyl]-,ethyl ester;Ethyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate;Tazorac;Zorac;AGN 190168;
Molecular FormulaC21H21NO2S
Molecular Weight351.46194
Chemical Properties
AppearanceWhite Solid
refractive index1.624
Toxicity

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US5675100
CHEMICAL NAME :
3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl )ethynyl)-, ethyl ester
CAS REGISTRY NUMBER :
118292-40-3
LAST UPDATED :
199801
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C21-H21-N-O2-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) 1979- Volume(issue)/page/year: 37(Suppl),S25,1997 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
22750 ug/kg/13W-I
TOXIC EFFECTS :
Musculoskeletal - other changes
REFERENCE :
JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) 1979- Volume(issue)/page/year: 37(Suppl),S25,1997
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
35 mg/kg/26W-I
TOXIC EFFECTS :
Musculoskeletal - other changes
REFERENCE :
JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) 1979- Volume(issue)/page/year: 37(Suppl),S25,1997

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