D-Mannitol,1,6-dimethanesulfonate cas no:1187-00-4

Synonyms: Mannitol,1,6-dimethanesulfonate, D- (8CI); 1,6-Bis(methanesulfonyl)-D-mannitol;1,6-Dimesyl-D-mannitol; 1,6-Dimethanesulfonyl-D-mannitol;1,6-Dimethanesulfonyloxy-1,6-dideoxy-D-mannitol; Busulfan mannitol; CB 2511;D-Mannitol busulfan; D-Mannitol busulphan; MM; Mannitol Myleran; Mannitolbusulfan; Mannogranol; NSC 37538

Identification

NameD-Mannitol,1,6-dimethanesulfonate
CAS1187-00-4
SynonymsMannitol,1,6-dimethanesulfonate, D- (8CI); 1,6-Bis(methanesulfonyl)-D-mannitol;1,6-Dimesyl-D-mannitol; 1,6-Dimethanesulfonyl-D-mannitol;1,6-Dimethanesulfonyloxy-1,6-dideoxy-D-mannitol; Busulfan mannitol; CB 2511;D-Mannitol busulfan; D-Mannitol busulphan; MM; Mannitol Myleran; Mannitolbusulfan; Mannogranol; NSC 37538
Molecular FormulaC8H18 O10 S2
Molecular Weight338.38

Chemical Properties

refractive index1.553

Safety Data

Safety

Poison by intravenous route. Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of SO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	135mg/kg (135mg/kg)	BLOOD: LEUKOPENIA BLOOD: AGRANULOCYTOSIS BLOOD: OTHER CHANGES	Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 203, 1965.
monkey	LDLo	intravenous	135mg/kg (135mg/kg)	BLOOD: LEUKOPENIA BLOOD: AGRANULOCYTOSIS BLOOD: OTHER CHANGES	Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 203, 1965.
mouse	LD50	intraperitoneal	2500mg/kg (2500mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 145, 1967.
mouse	LD50	oral	6gm/kg (6000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 145, 1967.
rat	LD50	intraperitoneal	2gm/kg (2000mg/kg)	BLOOD: NORMOCYTIC ANEMIA BLOOD: THROMBOCYTOPENIA	European Journal of Cancer. Vol. 4, Pg. 617, 1968.

supplier list

Nagase Group: Tel:+81-3-36653021; Address: 5-1, Nihonbashi-Kobunacho, Chuo-ku, Tokyo