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Gemcitabine hydrochloride cas no:122111-03-9

Synonyms: Gemcitabine HCl;2',2'-Difluorodeoxycytidine monohydrochloride;2'-Deoxy-2',2'-difluorocytidine monohydrochloride;2'-Deoxy-2',2'-difluorocytidine monohydrochloride (beta-isomer);

Identification
NameGemcitabine hydrochloride
CAS122111-03-9
SynonymsGemcitabine HCl;2',2'-Difluorodeoxycytidine monohydrochloride;2'-Deoxy-2',2'-difluorocytidine monohydrochloride;2'-Deoxy-2',2'-difluorocytidine monohydrochloride (beta-isomer);
Molecular FormulaC9H11F2N3O4.HCl
Molecular Weight299.66
Chemical Properties
AppearanceWhite crystalline granular, odorless
Safety Data

Hazard Xi: Irritant;
Risk R21
Safety

Hazard Codes:?HarmfulXn,Xi
Risk Statements: 21-36/38-46-62-63
R21: Harmful in contact with skin.
R36/38: Irritating to eyes and skin.?
R46: May cause heritable genetic damage.?
R62: Risk of impaired fertility.?
R63: Possible risk of harm to the unborn child.
Safety Statements: 25-26-36/37-53
S25: Avoid contact with eyes.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37: Wear suitable protective clothing and gloves.?
S53: Avoid exposure - obtain special instructions before use.
Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NOx, HCl, and F?.


Toxicity

?

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 500mg/kg (500mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 391, 2000.
rat LD50 intravenous 236mg/kg (236mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 391, 2000.
women TDLo parenteral 300mg/kg/12W- (300mg/kg) LUNGS, THORAX, OR RESPIRATION: CONSOLIDATION

LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Cancer Vol. 80, Pg. 286, 1997.

supplier list

Shandong Novatech Pharmaceutical Co., Ltd.
Tel:+86-531-55582725
Address: R801,Lianggu Building, No.6 Qilihe Road,
Nanjing Elegant Nutraceuticals Co.,Ltd.
Tel:
Address: Room A233, Weifen Hotel,28 North Yunnan Road,Nanjing The P. R. China
Tianjin Harmony Technology Development Co., Ltd.
Tel:
Address: Room 601 of BokeBuilding, 100 Fukang Road, Tianjin, China
Ningbo Distant Chemicals Co.,Ltd
Tel:
Address: 14-04,NO 668,Jingjia road,Jiangdong district,Ningbo,China
Shanghai Mingdou Chemical Co.,Ltd
Tel:86-21-52912919
Address: Floor 12th, Zhenyuan Building ,No 2052.North Zhongshan Road, Shanghai,China
IFFECT CHEMPHAR CO., LTD.
Tel:86-25-84679300
Address: 509, FuXin International Building, No.359 HongWu R
SHILPA MEDICARE LIMITED,
Tel:+0091-8532-235006, 236328
Address: 10/80, RAJENDRA GUNJ,RAICHUR - 584 102 (INDIA)
Sinoway Chemical Co., Ltd.
Tel:
Address: 16/F,Huicheng Comm,Complex,No839 XiaHe Rd, Xiamen,China
Pharmasi Chemicals Co.,Ltd
Tel:
Address: Room 205, Renlesancun50-29,songjiang,shanghai,China
Shanghai Kindtrust Trading Co., Ltd.
Tel:
Address: Room 7C, NO.1 Building, Dapu Road #38,Shanghai 200023, P. R. China
Shaoxing Hantai Imports & Exports Co., Ltd.
Tel:+86-575-86165119 86165129 13906856234
Address: 10B-2 JIAYI Plaza, No 127 Renming E Rd., Xinchang, Zhejiang, China
SUZHOU UNITE PHARMACEUTICAL CO.,LTD.
Tel:86-512-87666020
Address: ROOM NO.101,B BUILDING ,NO.31 NORTH DONGWU ROAD SUZHOU CHINA
Andard-Mount Company Limited
Tel:020-8991-5150
Address: 20 HANOVER SQUARE,LONDON,W1S 1JY
Hangzhou Rongda Pharm & Chem Co, Ltd.
Tel:0571-28889928
Address: Xinqiao Development Zone, Yuhang, Hangzhou, China
Shanghai Longschem Co.,Ltd
Tel:
Address: Shanghai Jincheng Road 338 6# 1002 Room

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