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Gemcitabine hydrochloride cas no:122111-03-9

Synonyms: Gemcitabine HCl;2',2'-Difluorodeoxycytidine monohydrochloride;2'-Deoxy-2',2'-difluorocytidine monohydrochloride;2'-Deoxy-2',2'-difluorocytidine monohydrochloride (beta-isomer);

Identification
NameGemcitabine hydrochloride
CAS122111-03-9
SynonymsGemcitabine HCl;2',2'-Difluorodeoxycytidine monohydrochloride;2'-Deoxy-2',2'-difluorocytidine monohydrochloride;2'-Deoxy-2',2'-difluorocytidine monohydrochloride (beta-isomer);
Molecular FormulaC9H11F2N3O4.HCl
Molecular Weight299.66
Chemical Properties
AppearanceWhite crystalline granular, odorless
Safety Data

Hazard Xi: Irritant;
Risk R21
Safety

Hazard Codes:?HarmfulXn,Xi
Risk Statements: 21-36/38-46-62-63
R21: Harmful in contact with skin.
R36/38: Irritating to eyes and skin.?
R46: May cause heritable genetic damage.?
R62: Risk of impaired fertility.?
R63: Possible risk of harm to the unborn child.
Safety Statements: 25-26-36/37-53
S25: Avoid contact with eyes.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37: Wear suitable protective clothing and gloves.?
S53: Avoid exposure - obtain special instructions before use.
Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NOx, HCl, and F?.


Toxicity

?

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 500mg/kg (500mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 391, 2000.
rat LD50 intravenous 236mg/kg (236mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 391, 2000.
women TDLo parenteral 300mg/kg/12W- (300mg/kg) LUNGS, THORAX, OR RESPIRATION: CONSOLIDATION

LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Cancer Vol. 80, Pg. 286, 1997.

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Nanjing Elegant Nutraceuticals Co.,Ltd.
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Address: Room A233, Weifen Hotel,28 North Yunnan Road,Nanjing The P. R. China
Ningbo Distant Chemicals Co.,Ltd
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Hangzhou Starshine Pharmaceutical Co., LTD
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Address: Fengqi East Road, Hangzhou, China.
SHILPA MEDICARE LIMITED,
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Address: 10/80, RAJENDRA GUNJ,RAICHUR - 584 102 (INDIA)
Sinoway Chemical Co., Ltd.
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Pharmasi Chemicals Co.,Ltd
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Address: Room 205, Renlesancun50-29,songjiang,shanghai,China
Shanghai Kindtrust Trading Co., Ltd.
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Shaoxing Hantai Imports & Exports Co., Ltd.
Tel:+86-575-86165119 86165129 13906856234
Address: 10B-2 JIAYI Plaza, No 127 Renming E Rd., Xinchang, Zhejiang, China
Andard-Mount Company Limited
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Address: 20 HANOVER SQUARE,LONDON,W1S 1JY
Axitec Co.,Ltd
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Address: 11B Real Estate Building Ren Min Road,South Luohu District ShenZhen ,PR China
Hangzhou Haichem Co., Ltd.
Tel:+86-571-86025531 86024803
Address: 1218-24, Guangyin Mansion, 42 Fengqi East Road,Hangzhou, China
Shanghai Kinding Industrial Co., Ltd
Tel:+86-21-26226658 68938887
Address: No. 347 Yushan Rd., Shanghai, China
Hangzhou Pharma & Chem Co.,Ltd.
Tel:+86-571-87040515
Address: Rm.1201,QinglianBldg.No,139QingchunRd,HangzhouCity,Zhejiang,China
Changzhou Xixialong International Trade Co.,ltd.
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Address: Room 5002, Modern city,Huangshanlu, Xinbei district, Changzhou, China
Jingzhou Netchem Pharm. & Chem Co., Ltd
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Address: Oriental Road High-tech Development Zone Jingzhou Hubei Province, P.R.China

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