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Gemcitabine hydrochloride cas no:122111-03-9

Synonyms: Gemcitabine HCl;2',2'-Difluorodeoxycytidine monohydrochloride;2'-Deoxy-2',2'-difluorocytidine monohydrochloride;2'-Deoxy-2',2'-difluorocytidine monohydrochloride (beta-isomer);

Identification
NameGemcitabine hydrochloride
CAS122111-03-9
SynonymsGemcitabine HCl;2',2'-Difluorodeoxycytidine monohydrochloride;2'-Deoxy-2',2'-difluorocytidine monohydrochloride;2'-Deoxy-2',2'-difluorocytidine monohydrochloride (beta-isomer);
Molecular FormulaC9H11F2N3O4.HCl
Molecular Weight299.66
Chemical Properties
AppearanceWhite crystalline granular, odorless
Safety Data

Hazard Xi: Irritant;
Risk R21
Safety

Hazard Codes:?HarmfulXn,Xi
Risk Statements: 21-36/38-46-62-63
R21: Harmful in contact with skin.
R36/38: Irritating to eyes and skin.?
R46: May cause heritable genetic damage.?
R62: Risk of impaired fertility.?
R63: Possible risk of harm to the unborn child.
Safety Statements: 25-26-36/37-53
S25: Avoid contact with eyes.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37: Wear suitable protective clothing and gloves.?
S53: Avoid exposure - obtain special instructions before use.
Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NOx, HCl, and F?.


Toxicity

?

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 500mg/kg (500mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 391, 2000.
rat LD50 intravenous 236mg/kg (236mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 391, 2000.
women TDLo parenteral 300mg/kg/12W- (300mg/kg) LUNGS, THORAX, OR RESPIRATION: CONSOLIDATION

LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Cancer Vol. 80, Pg. 286, 1997.

supplier list

Shanghai Asarum Biotechnology Co., Ltd
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Address: Room 404 SiPing road No.1128 YangPu district ShangHai China
Sinoway Chemical Co., Ltd.
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Address: 16/F,Huicheng Comm,Complex,No839 XiaHe Rd, Xiamen,China
Axitec Co.,Ltd
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Address: 11B Real Estate Building Ren Min Road,South Luohu District ShenZhen ,PR China
Changzhou Xixialong International Trade Co.,ltd.
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Address: Room 5002, Modern city,Huangshanlu, Xinbei district, Changzhou, China
Chemagis
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Address:
Axitec Co., Ltd.
Tel:+86-(755)-26491310
Address: 1415 HuiXiu Building,HuiBing Square, DongBing Road, Shenzhen, Guangdong 518068,
Xi'an Biosun Technique Co., Ltd.
Tel:+86-(29)-83399206
Address: No.99 YanXiang Road, Biosep Building, Xi'an, Shaanxi 710054,
Lianyungang Jinkang Pharmaceutical Technology Co., Ltd.
Tel:0086-0518-85445517
Address: Jinshan Industrial Park, Ganyu County, Lianyungang, Jiangsu 222115,
Changzhou Joyous Chemical Co., Ltd.
Tel:+86-(519)-8560 7258
Address: 1201/1203,Bldg2,Fuchen Commercial Plaza, Xinbei District, Changzhou, Jiangsu,
BrightGene Bio-Medical Technology Co., Ltd.
Tel:+86-(512)-68086131
Address: No.1326, Binhe Road, Suzhou New district, Suzhou, Jiangsu 215011,
Parling Trading Company
Tel:
Address:
Suqian Mingyuan Technology Development Co. Ltd.
Tel:+86-(527)-82860866
Address: A27, Building, NO.88 Fumin Road, Economic Development Zone, Suqian, Jiangsu 223800,
Changzhou Xinjin Chemical Co., Ltd.
Tel:+86-(519)-85155231/85155232
Address: No.555,Tongjiang Road, Changzhou, Jiangsu 213003,
Hande Pharma Limited
Tel:+86-(755)-26031808
Address: No.2-405A & 405B, Bio-incubator Bldg., Gaoxinzhong 1st Rd., Shenzhen Hi-tech Industrial Park, Shenzhen, Guangdong 518057,
Coben Pharmaceutical Co., Ltd.
Tel:+86-(571)-28021577
Address: B-17/F of Haihua Plaza , No.658 North Jianguo Road, Hangzhou, Zhejiang 310004,

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