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4-Hydroxy-4-methyl-2-pentanone cas no:123-42-2

Synonyms: Diacetone alcohol; 2-Hydroxy-2-methyl-4-pentanone; 2-methyl-2-pentanol-4-one; 4-Hydroxy-2-keto-4-methylpentane; 4-hydroxy-4-methylpentan-2-one; 4-Methyl-4-Hydroxy-2-pentanone; Acetonyldimethylcarbinol; Diacetone; Diketone Alcohol; Tyranton

Identification
Name4-Hydroxy-4-methyl-2-pentanone
CAS123-42-2
SynonymsDiacetone alcohol; 2-Hydroxy-2-methyl-4-pentanone; 2-methyl-2-pentanol-4-one; 4-Hydroxy-2-keto-4-methylpentane; 4-hydroxy-4-methylpentan-2-one; 4-Methyl-4-Hydroxy-2-pentanone; Acetonyldimethylcarbinol; Diacetone; Diketone Alcohol; Tyranton
EINECS(EC#)204-626-7
Molecular FormulaC6H12O2
Molecular Weight116.16
Chemical Properties
AppearanceClear, colorless liquid
refractive index1.4223-1.4243
storage tempStore in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass3
Safety Data

Hazard Xi:Irritant
Risk R36
Safety

Safety Information for Diacetone alcohol(123-42-2)
Hazard Codes:?IrritantXi
Risk Statements: 36
36: Irritating to eyes
Safety Statements: 24/25
S24/25: Avoid contact with skin and eyes.
RIDADR: UN 1148 3/PG 3
WGK: Germany 1
RTECS: SA9100000
F: 9
HazardClass: 3
PackingGroup: III
Moderately toxic by ingestion and intraperitoneal routes. Mildly toxic by skin contact. Human systemic effects by inhalation: headache, nausea or vomiting, eye and pulmonary changes. A skin, mucous membrane, and severe eye irritant. Can cause anemia and damage to liver and kidneys. Narcotic in high concentration. Flammable liquid when exposed to heat or flame; can react with oxidizing materials. Explosive in the form of vapor when exposed to heat or flame. To fight fire, use alcohol foam, foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TCLo inhalation 100ppm (100ppm) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: HEADACHE

GASTROINTESTINAL: NAUSEA OR VOMITING
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 21, 1974.
human TCLo inhalation 400ppm (400ppm) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 21, 1974.
mouse LD50 intraperitoneal 933mg/kg (933mg/kg) ? Shell Chemical Company. Unpublished Report. Vol. -, Pg. 3, 1961.
mouse LD50 oral 3950mg/kg (3950mg/kg) ? Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 669, 1956.
rabbit LD50 skin 13500mg/kg (13500mg/kg) ? Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 21, 1974.
rabbit LDLo intramuscular 2792mg/kg (2792mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Pharmacology and Experimental Therapeutics. Vol. 33, Pg. 175, 1928.
rabbit LDLo intravenous 2792mg/kg (2792mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Journal of Pharmacology and Experimental Therapeutics. Vol. 33, Pg. 175, 1928.
rabbit LDLo oral 4653mg/kg (4653mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Journal of Pharmacology and Experimental Therapeutics. Vol. 33, Pg. 175, 1928.
rat LCLo inhalation 1000ppm/4H (1000ppm) ? National Technical Information Service. Vol. OTS0557741,
rat LD50 oral 2520mg/kg (2520mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LIVER: OTHER CHANGES
National Technical Information Service. Vol. OTS0557732,
rat LDLo intravenous 3024mg/kg (3024mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: COMA
Journal of Pharmacology and Experimental Therapeutics. Vol. 33, Pg. 175, 1928.

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