1,4-Dioxane cas no:123-91-1

Hazard F:Flammable
Risk R11;R19;R36/37;R40;R66
Safety

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by intraperitoneal route. Moderately toxic by ingestion and inhalation. Mildly toxic by skin contact. Human systemic effects by inhalation: lachrymation, conjunctiva irritation, convulsions, high blood pressure, unspecified respiratory and gastrointestinal system effects. Mutation data reported. An eye and skin irritant. The irritant effects probably provide sufficient warning, in acute exposures, to enable a worker to leave exposure before being seriously affected. Repeated exposure to low concentrations has resulted in human fatalities, the organs chiefly affected being the liver and kidneys.
A very dangerous fire and explosion hazard when exposed to heat or flame; can react vigorously with oxidizing materials. Violent reaction with (H₂ + Raney Ni), AgClO₄. Can form dangerous peroxides when exposed to air. Potentially explosive reaction with nitric acid + perchloric acid, Raney nickel catalyst (above 210°C). Forms explosive mixtures with decaborane (impact-sensitive), triethynylaluminum (sensitive to heating or drying). Violent reaction with sulfur trioxide. Incompatible with sulfur trioxide. To fight fire, use alcohol foam, CO₂, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also GLYCOL ETHERS.
The Hazard Codes of? ?: ?Xn,?? F,? T
The Risk Statements information of?Dioxane (CAS NO.123-91-1):
11:? Highly Flammable?
19:? May form explosive peroxides?
40:? Limited evidence of a carcinogenic effect?
41:? Risk of serious damage to eyes?
45:? May cause cancer?
46:? May cause heritable genetic damage?
36/37/38:? Irritating to eyes, respiratory system and skin?
39/23/24/25:? Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed?
48/20/22:? Harmful: danger of serious damage to health by prolonged exposure through inhalation and if swallowed?
The Safety Statements information:
7:? Keep container tightly closed?
9:? Keep container in a well-ventilated place?
16:? Keep away from sources of ignition - No smoking?
23:? Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)?
26:? In case of contact with eyes, rinse immediately with plenty of water and seek medical advice?
45:? In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)?
46:? If swallowed, seek medical advice immediately and show this container or label?
53:? Avoid exposure - obtain special instruction before use?
62:? If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label
24/25:? Avoid contact with skin and eyes?
36/37:? Wear suitable protective clothing and gloves?
RIDADR?: UN 1993 3/PG 2
WGK Germany:? 3