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Azelnidipine cas no:123524-52-7

Synonyms: Calblock;CS 905;3,5-Pyridinedicarboxylic acid, 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl) 5-(1-methylethyl) ester, (+-)-;3-(1-(Diphenylmethyl)-3-azetidinyl) 5-isopropyl (+-)-2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate;Calblock (TN);(1-benzhydrylazetidin-3-yl) propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;Azelidipine;2-Amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxy lic acid 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(methylethyl) ester;

Identification
NameAzelnidipine
CAS123524-52-7
SynonymsCalblock;CS 905;3,5-Pyridinedicarboxylic acid, 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl) 5-(1-methylethyl) ester, (+-)-;3-(1-(Diphenylmethyl)-3-azetidinyl) 5-isopropyl (+-)-2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate;Calblock (TN);(1-benzhydrylazetidin-3-yl) propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;Azelidipine;2-Amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxy lic acid 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(methylethyl) ester;
Molecular FormulaC33H34N4O6
Molecular Weight582.65
Chemical Properties
Appearancelight yellowish powder
refractive index1.658
storage tempRoom temp
Safety Data

Hazard Xn
Risk R22
Safety

Hazard Codes?Azelnidipine (CAS NO.123524-52-7):?Xn
Risk Statements:?22-41
Safety Statements:?26-39
RTECS:?US7968332


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 800mg/kg (800mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: NAUSEA OR VOMITING
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl,
mouse LD50 oral 785mg/kg (785mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl,
rat LD50 oral 1267mg/kg (1267mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ATAXIA

MUSCULOSKELETAL: OTHER CHANGES
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl,

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Chemner Pharma
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