(+)-Griseofulvin cas no:126-07-8
Synonyms: Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione,7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'S-trans)-;7-Chloro-2',4,6-trimethoxy-6'b-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione;Amudane;Curling factor;Fulcin;Fulvicin;Fulvicin P/G;Fulvicin U/F;Fulvidex;Fulvina;Fulvinil;Fulvistatin;Gricin;Grifulin;Grifulvin;Gris-PEG;Grisactin;Grisefulin;Griseofulvin, (+)-;Grisofulvin;Grisovin;Grysio;Idifulvin;Likuden;Polygris;Poncyl;Spirofulvin;Xuanjing;
Name(+)-Griseofulvin
CAS126-07-8
SynonymsSpiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione,7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'S-trans)-;7-Chloro-2',4,6-trimethoxy-6'b-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione;Amudane;Curling factor;Fulcin;Fulvicin;Fulvicin P/G;Fulvicin U/F;Fulvidex;Fulvina;Fulvinil;Fulvistatin;Gricin;Grifulin;Grifulvin;Gris-PEG;Grisactin;Grisefulin;Griseofulvin, (+)-;Grisofulvin;Grisovin;Grysio;Idifulvin;Likuden;Polygris;Poncyl;Spirofulvin;Xuanjing;
EINECS(EC#)204-767-4
Molecular FormulaC17H17ClO6
Molecular Weight352.77
AppearanceWhite to pale cream-colored crystalline powder. Odorless or almost odorless. Tasteless.
alpha354 o (C=1, DIMETHYLFORM)
refractive index1.565
storage temp?20°C
Hazard T:Toxic
Risk R60;R61;R40;R43
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- WG9800000
- CHEMICAL NAME :
- Spiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione,
7-chloro-2'4,6-trimethoxy-6'-beta- methyl-
- CAS REGISTRY NUMBER :
- 126-07-8
- BEILSTEIN REFERENCE NO. :
- 0095226
- LAST UPDATED :
- 199801
- DATA ITEMS CITED :
- 53
- MOLECULAR FORMULA :
- C17-H17-Cl-O6
- MOLECULAR WEIGHT :
- 352.79
- WISWESSER LINE NOTATION :
- T56 BOXVJ FO1 HO1 IG C-& DL6V DX BUTJ CO1 E1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Blood - changes in cell count (unspecified)
Blood - changes in bone marrow (not otherwise specified)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >50 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >12 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 280 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 109 gm/kg/52W-C
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 462 gm/kg/2Y-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 440 gm/kg/52W-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 120 mg/kg/49W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 730 gm/kg/52W-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1250 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2 gm/kg
- SEX/DURATION :
- female 11-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - urogenital system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 12500 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 500 mg/kg
- SEX/DURATION :
- female 9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - eye/ear
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 10 gm/kg
- SEX/DURATION :
- female 8-9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1 gm/kg
- SEX/DURATION :
- female 48-52 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- Specific locus test
- TYPE OF TEST :
- DNA repair
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Sister chromatid exchange
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Sperm Morphology
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Bird - chicken Fibroblast
- DOSE/DURATION :
- 50 mg/L
- REFERENCE :
- NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 253,361,1975
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,391,1987
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 7,391,1987
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
LLOYA2 Lloydia. (Cincinnati, OH) V.1-41, 1938-78. For publisher
information, see JNPRDF. Volume(issue)/page/year: 38,21,1975
TOXICOLOGY REVIEW
32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York,
Springer, 1975 Volume(issue)/page/year: -,49,1975
TOXICOLOGY REVIEW
ARMIAZ Annual Review of Microbiology. (Annual Reviews, Inc., POB 10139,
Palo Alto, CA 94303) V.1- 1947- Volume(issue)/page/year: 26,279,1972
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3685
No. of Facilities: 58 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 1656 (estimated)
No. of Female Employees: 774 (estimated)
