D-Streptamine, O-2-amino-2-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1-3)-beta-D-ribofuranosyl-(1-5))-2-deoxy-, sulfate (salt) cas no:1263-89-4
Synonyms: Aminosidine Sulphate;Paromomycin sulfate salt;Humatin (TN);Paromomycin sulfate (JAN/USP);Prestwick_1023;D-Streptamine,O-2-amino-2-deoxy-R-Dglucopyranosyl-( 1f4)-O-[O-2,6-diamino-2,- 6-dideoxy-a-L-idopyranosyl-(1f3)-a-Dribofuranosyl-( 1f5)]-2-deoxy-,sulfate (salt);Paromomycin sulfate;Gabbroral;Humatin;5-amino-6-[4,6-diamino-2-[(3S,4S,5R)-4-[3-amino-6-(aminomethyl)-4,5-dihydroxy-oxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-2-(hydroxymethyl)oxane-3,4-diol; sulfuric acid;(2R,3S,4R,5R,6S)-5-amino-6-[(1R,2S,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4R,5R)-4-[(2R,3R,4R,5R,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxy-oxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-2-(hydroxymethyl)oxane-3,4-diol; sulfuric acid;
NameD-Streptamine, O-2-amino-2-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1-3)-beta-D-ribofuranosyl-(1-5))-2-deoxy-, sulfate (salt)
CAS1263-89-4
SynonymsAminosidine Sulphate;Paromomycin sulfate salt;Humatin (TN);Paromomycin sulfate (JAN/USP);Prestwick_1023;D-Streptamine,O-2-amino-2-deoxy-R-Dglucopyranosyl-( 1f4)-O-[O-2,6-diamino-2,- 6-dideoxy-a-L-idopyranosyl-(1f3)-a-Dribofuranosyl-( 1f5)]-2-deoxy-,sulfate (salt);Paromomycin sulfate;Gabbroral;Humatin;5-amino-6-[4,6-diamino-2-[(3S,4S,5R)-4-[3-amino-6-(aminomethyl)-4,5-dihydroxy-oxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-2-(hydroxymethyl)oxane-3,4-diol; sulfuric acid;(2R,3S,4R,5R,6S)-5-amino-6-[(1R,2S,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4R,5R)-4-[(2R,3R,4R,5R,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxy-oxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-2-(hydroxymethyl)oxane-3,4-diol; sulfuric acid;
EINECS(EC#)215-031-7
Molecular FormulaC23H45N5O14•H2O4S
Molecular Weight615.6285
AppearanceYellow powder
storage temp0-6°C
Hazard Xi
Risk R23/24/25;R36/38;R39/23/24/25
Safety
Poison by intravenous, subcutaneous, and intramuscular routes. Mildly toxic by ingestion. Mutation data reported. See also SULFATES. When heated to decomposition it emits very toxic fumes of SOx and NOx.
Hazard Codes:
Xi: Irritant .gif)
Risk Statements about ANTIBIOTIC 1600 (1263-89-4):
R61 May cause harm to the unborn child.
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements about ANTIBIOTIC 1600 (1263-89-4):
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 Wear suitable protective clothing.
S38 In case of insufficient ventilation, wear suitable respiratory equipment.
S45 In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37: Wear suitable protective clothing and gloves.
| guinea pig |
LD50 |
subcutaneous |
1700mg/kg (1700mg/kg) |
|
Chemotherapy Vol. 16, Pg. 105, 1968. |
| monkey |
LDLo |
intravenous |
93mg/kg (93mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Antibiotics and Chemotherapy Vol. 9, Pg. 730, 1959. |
| mouse |
LD50 |
intracrebral |
22300ug/kg (22.3mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Chemotherapy Vol. 16, Pg. 114, 1968. |
| mouse |
LD50 |
intramuscular |
438mg/kg (438mg/kg) |
|
Japanese Journal of Antibiotics. Vol. 36, Pg. 644, 1983. |
| mouse |
LD50 |
intraperitoneal |
750mg/kg (750mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Chemotherapy Vol. 16, Pg. 114, 1968. |
| mouse |
LD50 |
intravenous |
90mg/kg (90mg/kg) |
|
Therapie. Vol. 16, Pg. 184, 1961. |
| mouse |
LD50 |
oral |
23500mg/kg (23500mg/kg) |
|
Japanese Journal of Antibiotics. Vol. 36, Pg. 644, 1983. |
| mouse |
LD50 |
subcutaneous |
123mg/kg (123mg/kg) |
|
Therapie. Vol. 16, Pg. 184, 1961. |
| rat |
LD50 |
intramuscular |
1200mg/kg (1200mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 595, 1982. |
| rat |
LD50 |
intravenous |
181mg/kg (181mg/kg) |
|
Antibiotics and Chemotherapy Vol. 9, Pg. 730, 1959. |
| rat |
LD50 |
oral |
21620mg/kg (21620mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 595, 1982. |
| rat |
LD50 |
subcutaneous |
870mg/kg (870mg/kg) |
PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE |
Chemotherapy Vol. 16, Pg. 114, 1968. |
