Pregn-4-ene-3,20-dione,9-fluoro-11,17,21-trihydroxy-, (11b)- cas no:127-31-1
Synonyms: Pregn-4-ene-3,20-dione,9-fluoro-11b,17,21-trihydroxy- (7CI,8CI);9-Fluoro-11b,17,21-trihydroxypregn-4-ene-3,20-dione;9-Fluorocortisol;9-Fluorohydrocortisone;9a-Fludrocortisone;9a-Fluorcortisol;9a-Fluoro-11b,17a,21-trihydroxy-4-pregnene-3,20-dione;9a-Fluoro-17-hydroxycorticosterone;9a-Fluorocortisol;9a-Fluorohydrocortisone;Alflorone;Astonin-H;Florinef;Fludrocortone;Fludrone;Fluohydrocortisone;Fluorocortisol;Fluorohydrocortisone;NSC 11318;
NamePregn-4-ene-3,20-dione,9-fluoro-11,17,21-trihydroxy-, (11b)-
CAS127-31-1
SynonymsPregn-4-ene-3,20-dione,9-fluoro-11b,17,21-trihydroxy- (7CI,8CI);9-Fluoro-11b,17,21-trihydroxypregn-4-ene-3,20-dione;9-Fluorocortisol;9-Fluorohydrocortisone;9a-Fludrocortisone;9a-Fluorcortisol;9a-Fluoro-11b,17a,21-trihydroxy-4-pregnene-3,20-dione;9a-Fluoro-17-hydroxycorticosterone;9a-Fluorocortisol;9a-Fluorohydrocortisone;Alflorone;Astonin-H;Florinef;Fludrocortone;Fludrone;Fluohydrocortisone;Fluorocortisol;Fluorohydrocortisone;NSC 11318;
EINECS(EC#)204-833-2
Molecular FormulaC21H29FO5
Molecular Weight380.50
AppearanceWhite solid
refractive index1.563
Safety Poison by intraperitoneal route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of F−. See also PREDNISONE.
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TU5025000
- CHEMICAL NAME :
- Pregn-4-ene-3,20-dione,
9-fluoro-11-beta,17,21-trihydroxy-
- CAS REGISTRY NUMBER :
- 127-31-1
- BEILSTEIN REFERENCE NO. :
- 3014278
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C21-H29-F-O5
- MOLECULAR WEIGHT :
- 380.50
- WISWESSER LINE NOTATION :
- L E5 B666 OV MUTJ A1 BF CQ E1 FV1Q FQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 170 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of
National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
Ont., Canada)
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- DOSE :
- 8750 ug/kg
- SEX/DURATION :
- female 7 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - uterus, cervix, vagina
- REFERENCE :
- JEMEAV Journal of Experimental Medicine. (Rockefeller Univ. Press, 1230
York Ave., New York, NY 10021) V.1- 1896- Volume(issue)/page/year:
102,347,1955
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 100 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
- REFERENCE :
- 28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th
International Committee on Laboratory Animals, Hanover, 1972," Speigel, A.
ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973
Volume(issue)/page/year: -,85,1973
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1 mg/kg
- SEX/DURATION :
- female 13-16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- 28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th
International Committee on Laboratory Animals, Hanover, 1972," Speigel, A.
ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973
Volume(issue)/page/year: -,85,1973
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2 mg/kg
- SEX/DURATION :
- female 13-16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
- REFERENCE :
- 28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th
International Committee on Laboratory Animals, Hanover, 1972," Speigel, A.
ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973
Volume(issue)/page/year: -,85,1973
