Pazufloxacin cas no:127045-41-4
Synonyms: Pasil;Pasil (TN);PZFX;7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 2,3-dihydro-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-, (S)-;7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6- carboxylic acid,10-(1-aminocyclopropyl)-9- fluoro-2,3-dihydro-3-methyl-7-oxo-,(3S)-;T 3761;(-)-(3S)-10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid;7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (S)-;T-3761;Pazufloxacin Mesylas;Pazufloxaxin;(S)-10-(1-aminocyclopropyl)-9-fluoro-3-methy...;
NamePazufloxacin
CAS127045-41-4
SynonymsPasil;Pasil (TN);PZFX;7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 2,3-dihydro-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-, (S)-;7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6- carboxylic acid,10-(1-aminocyclopropyl)-9- fluoro-2,3-dihydro-3-methyl-7-oxo-,(3S)-;T 3761;(-)-(3S)-10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid;7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (S)-;T-3761;Pazufloxacin Mesylas;Pazufloxaxin;(S)-10-(1-aminocyclopropyl)-9-fluoro-3-methy...;
Molecular FormulaC16H15FN2O4
Molecular Weight318.3
Appearancelike white to light yellow crystalline
refractive index1.692
storage tempStore in original container in a cool dark place.
Hazard Xn: Harmful;
Risk R20/21/22
Safety
Hazard Codes: 
Xn,
C,
F
Risk Statements: 20/21/22-34-11
R11: Pazufloxacin (CAS NO.127045-41-4)? is highly flammable.?
R34: Causes burns.?
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 45-36/37/39-26-16
S16: Keep Pazufloxacin (CAS NO.127045-41-4) away from sources of ignition.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
RTECS: UU8815300
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| dog |
LD |
oral |
> 2gm/kg (2000mg/kg) |
? |
Japanese Journal of Antibiotics. Vol. 48, Pg. 754, 1995. |
| dog |
LDLo |
intravenous |
400mg/kg (400mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
GASTROINTESTINAL: NAUSEA OR VOMITING |
Japanese Journal of Antibiotics. Vol. 48, Pg. 754, 1995. |
| mouse |
LD |
oral |
> 5gm/kg (5000mg/kg) |
? |
Japanese Journal of Antibiotics. Vol. 48, Pg. 754, 1995. |
| mouse |
LD |
subcutaneous |
> 5gm/kg (5000mg/kg) |
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Japanese Journal of Antibiotics. Vol. 48, Pg. 754, 1995. |
| mouse |
LD50 |
intravenous |
783mg/kg (783mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Japanese Journal of Antibiotics. Vol. 48, Pg. 754, 1995. |
| rat |
LD |
oral |
> 5gm/kg (5000mg/kg) |
? |
Chemotherapy Vol. 43(Suppl, |
| rat |
LD |
subcutaneous |
> 5gm/kg (5000mg/kg) |
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Japanese Journal of Antibiotics. Vol. 48, Pg. 754, 1995. |
| rat |
LD50 |
intravenous |
341mg/kg (341mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Japanese Journal of Antibiotics. Vol. 48, Pg. 754, 1995. |
