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N-Ethylmaleimide cas no:128-53-0

Synonyms: NEM; N-Ethylmaleimide, (NEM); 1-Ethyl-1H-pyrrole-2,5-dione~NEM

Identification
NameN-Ethylmaleimide
CAS128-53-0
SynonymsNEM; N-Ethylmaleimide, (NEM); 1-Ethyl-1H-pyrrole-2,5-dione~NEM
EINECS(EC#)204-892-4
Molecular FormulaC6H7NO2
Molecular Weight125.12
Chemical Properties
AppearanceWhite solid
refractive index1.514
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1
Safety Data

Hazard T+:Verytoxic;
Risk R20/21;R28;R34;R43
Safety

Poison by intraperitoneal route. Human mutation data reported. Vapors are highly irritating. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes:  T+ Very
Risk Statements:  21-28-34-43-20/21 
R21:Harmful in contact with skin. 
R28:Very toxic if swallowed. 
R34:Causes burns. 
R43:May cause sensitization by skin contact. 
R20/21:Harmful by inhalation and in contact with skin.
Safety Statements:  26-28-36/37/39-45-28
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S28:After contact with skin, wash immediately with plenty of soap-suds.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
R45:May cause cancer. 
R28:Very toxic if swallowed.  
RIDADR:  UN 2928 6.1/PG 2
WGK Germany:  3
RTECS:  UX9625000
F:  19
HazardClass:  6.1
PackingGroup:  II


Toxicity
1.    

dni-hmn:oth 6 µmol/L

    CNREA8    Cancer Research. 40 (1980),1414.
2.    

dni-mus:oth 300 µmol/L

    BBRCA9    Biochemical and Biophysical Research Communications. 106 (1982),1448.
3.    

dni-mus:oth 6 µmol/L

    CNREA8    Cancer Research. 40 (1980),1414.
4.    

dni-ham:lng 750 nmol/L

    32YWA5    Radiation Research, Biomedical, Chemical, and Physical Perspectives ,Nygaard, O.F., et al., ed.,New York, NY.: Academic,1975,742.
5.    

ipr-rat LDLo:17 mg/kg

    JMCMAR    Journal of Medicinal Chemistry. 15 (1972),534.
6.    

ipr-mus LD50:25 mg/kg

    NTIS**    National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) No. AD277-689 .

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