128-62-1|1(3H)-Isobenzofuranone,6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-,(3S)-Products Supply

1(3H)-Isobenzofuranone,6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-,(3S)- cas no:128-62-1

Synonyms: 1(3H)-Isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-,[S-(R*,S*)]-;Narcotine (7CI,8CI);(-)-Narcotine;(-)-a-Narcotine;Capval;Coscopin;L-a-Noscapine;Longactin;Longatin;Methoxyhydrastine;NSC 5366;Narcompren;Narcosine;Narcotin;Narcotussin;Nectadon;Nicolane;Nipaxon;Noscapin;Noscapine;Opian;Opianin;Opianine;Tusscapine;Vadebex;a-Narcotine;

Identification

Name1(3H)-Isobenzofuranone,6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-,(3S)-
CAS128-62-1
Synonyms1(3H)-Isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-,[S-(R*,S*)]-;Narcotine (7CI,8CI);(-)-Narcotine;(-)-a-Narcotine;Capval;Coscopin;L-a-Noscapine;Longactin;Longatin;Methoxyhydrastine;NSC 5366;Narcompren;Narcosine;Narcotin;Narcotussin;Nectadon;Nicolane;Nipaxon;Noscapin;Noscapine;Opian;Opianin;Opianine;Tusscapine;Vadebex;a-Narcotine;
EINECS(EC#)204-899-2
Molecular FormulaC₂₂H₂₃NO₇
Molecular Weight413.42

Chemical Properties

AppearanceCrystalline solid
alpha-200 º (C=1 IN CHLOROFORM)

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard Xn:Harmful;
Risk R22
Safety

Moderately toxic by ingestion and subcutaneous routes. Mutation data reported. An antitussive. When heated to decomposition it emits toxic fumes of NO_x.
Safety Information of Narcotine (128-62-1):
Hazard Codes: Xn
Risk Statements: 22
22: Harmful if swallowed

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	73200ug/kg (73.2mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 323, 1968.
mouse	LD50	intraperitoneal	960mg/kg (960mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 2331, 1982.
mouse	LD50	intravenous	83mg/kg (83mg/kg)		Toxicology and Applied Pharmacology. Vol. 3, Pg. 96, 1961.
mouse	LD50	oral	853mg/kg (853mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 2331, 1982.
mouse	LD50	subcutaneous	725mg/kg (725mg/kg)		Russian Pharmacology and Toxicology Vol. 31, Pg. 338, 1968.
rat	LD50	oral	1520mg/kg (1520mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 2331, 1982.

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1(3H)-Isobenzofuranone,6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-,(3S)- cas no:128-62-1

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